Lecture 7 Flashcards

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1
Q

Glutamine

A
  • Rapidly divides epithelial tissues in the gut
  • Regulates intestinal bacteria’s utilization
  • Metabolism of amino acids
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2
Q

FDA doesn’t test or regulate

A
  • make sure they are 3rd party tested
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3
Q

NSF certified sport

A
  • safe for athletes that are blood tested
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4
Q

St. John’s Wort

A
  • Important
  • a lot of interaction with other drug
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5
Q

Glucocorticoids

A
  • sone or olone endings
  • control of glucose metabolism in the body to deal with stress
  • Decrease inflammation & suppress immune system
  • Primarily used as anti-inflammatory or immunosuppressants
  • Evaluate / treat endocrine disorders
  • cortisol & corticosterone
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6
Q

Mineralocorticoids

A
  • Maintain fluid & electrolyte balance in the body
  • Orally
  • Aldosterone
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7
Q

Adrenal Glands

A
  • Inside: Medulla
  • Outside: Cortex
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8
Q

ADH & Aldosterone

A
  • ADH: Antidiuretic hormone
  • Aldosterone: Increases kidney secretion of sodium into bloodstream = Increase in BP
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9
Q

Addison’s Disease

A
  • Not enough cortisol and aldosterone
  • Adrenal insufficiency
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10
Q

Cushing’s Syndrome

A
  • Too much cortisol
  • A tumor in the pituitary gland that increases ACTH release resulting in increased cortisol
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11
Q

Addison’s Symptoms

A
  • Adrenal hypofunction
  • Hypoglycemia
  • Hypotension
  • Treated with corticosteroids
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12
Q

Cushing’s Symptoms

A
  • Adrenal hyperfunction
  • Weight gain in face and abdomen
  • Muscle weakness
  • Hyperglycemia
  • Hypertension
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12
Q

Physiological dose

A
  • roughly equal to what the body should be making
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13
Q

Pharmacological dose

A
  • Larger doses for a specific therapeutic effect
  • Trying to make a different change
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14
Q

Mineralocorticoid and glucocorticoid replacement is usually required in patients with?

A
  • Addison’s disease or other forms of adrenal hypofunction
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15
Q

Fludrocortisone (Florinef)

A
  • Primary aldosterone like agent for replacement therapy
16
Q

Adverse effects of Mineralocorticoids

A
  • Hypertension
  • Peripheral edema
  • Weight gain
  • Hypokalemia
17
Q

Mineralocorticoid antagonists

A
  • Spironolactone (Aldactone)
  • Eplerenone (Inspra)
  • Competitive antagonist to the aldosterone receptors
  • Increased sodium and water excretion
  • Decreased potassium excretion
  • Primarily used as diuretics in hypertension and heart failure
18
Q

Steroid Myopathy

A
  • Proximal muscle weakness
19
Q

Drugs for gastric acidity and secretion

A
  • Antacids: Neutralize stomach acids
  • H2 receptor blockers: prevent histamine activated release of gastric acid
  • Proton pump inhibitors: inhibit an enzyme that is responsible for gastric acid secretion
20
Q

Allopurinol

A
  • Treatment of gout
  • Oral medication
  • Reduces production of uric acid in the body
21
Q

Levodopa

A
  • Treatment of parkinson’s disease
  • Resolves dopamine deficiency by being converted to dopamine
  • Long term used limited by side effects
22
Q

Valacyclovir (Valtrex) & Acyclovir (Zovirax)

A
  • Effective against herpes and chicken pox
  • Inhibits viral DNA polymerase enzyme
  • can be topical or oral
  • avir endings
23
Q

Follicular

A
  1. Early follicular (Bleeding/Menstruation)
  2. Late follicular (Non-bleeding)
24
Q

Luteal (Ovulation characterizes change)

A
  1. Early luteal
  2. Late luteal
25
Q

Hormonal birth control

A
  • Pill usually a combination of estrogen and progesterone
  • Can be progesterone only
  • IUDs and arm implants are progesterone only
26
Q

BCP benefits

A
  • improve quality of life in people with endometriosis, PCOS, and other gynecological diseases / issues
  • can stabilize PMS symptoms
  • Lower risk of ovarian cancer
27
Q

BCP influences

A
  • Decreased hormonal variation and loss of normal infradian rhythm
  • Altered brain structure in areas related to emotion
  • Increased structural change with increased time
  • Alters microbiome leads to gut dysbiosis
28
Q
A