Lecture 1 Pharmacodynamics Flashcards
1
Q
Drug Receptor
A
Specific macromolecule that recognizes the drug
2
Q
What is required for drug to affect a specific action?
A
Drug Receptor
3
Q
Ability for drug to bind depends on which two factors?
A
- drug size
- shape relative to binding site
4
Q
Degree of affinity
A
degree of attraction or binding power a given drug has for the receptors
5
Q
Receptor
A
component on or within a cell that a substance can bind to
6
Q
Receptors on the cell surface
A
- Receptor sites on exterior of cell
- Will not specifically allow substance to enter cell
- Receptors are “transmembrane” proteins: Relay information from binding site to intracellular mechanism to cause change
7
Q
Proteins may have which two sites
A
- extracellular receptor site: binding domain
- intracellular enzymatic component: catalytic domain
8
Q
Example of insulin
A
- Binds to extracellular component of protein
- Activates protein enzymatic activity on inner surface of cell membrane
- Leads to glucose uptake in muscle cells
9
Q
Affinity
A
- Amount of attraction between the drug and the receptor
10
Q
Selective
A
- a type of drug that affects only one type of cell or tissue and produces a specific physiological response
- no drug produces only one effect
- example: Cardioselectivve drugs vs. GI system
11
Q
Dose Response
A
- Shape of curve is related to number of receptors bound by the drug
- Response is proportional to number of receptors occupied by the drug
12
Q
What happens as dosage increases?
A
- more receptors become occupied
- Dose response increases
13
Q
Agonist drug
A
- binds to a receptor and produces an action
- Affinity and efficacy
14
Q
Antagonist drug
A
- binds to a receptor and does not produce an action
- Only affinity
- can be called a blocker
example: Benadryl
15
Q
Partial Agonists
A
- do not evoke a maximal response
- often have high affinity for a receptor
- may not completely activate the receptor
