Lecture 61 - Bipolar Disorder Flashcards
The difference between Bipolar I and Bipolar II is that one is characterized by Manic episodes and the other is characterized by Hypomanic episodes AND Depressive episodes. Which is which?
Bipolar I –> Manic episodes
Bipolar II –> Hypomania and Depression
Mania and Hypomania are characterized by several days in a row of ______ or ______ mood with other symptoms included in the mnemonic DIGFAST.
What does DIGFAST stand for?
Elevated
Irritable
D –> Distractability
I –> Irresponsible behavior (beyond their norm)
G –> Grandiosity
F –> Flight of ideas or racing thoughts(ideas seem unrelated)
A –> Activity/increased goal direction (Keep in mind Mania is different than Hypomania in that Mania inhibits function, so a Manic person likely wouldn’t be able to complete goal, whereas a Hypomanic person likely would).
S –> Sleep (decreased need for it)
T –> Talking fast
________ is a first line Mood Stabilizer for Bipolar disorder. It needs to be kept in a tight therapeutic range with serum levels of _____ - _____.
It should not be given to patients with ______ disease, as it can cause ____toxicity. It can also cause Acne, Weight gain, and other lesser side effects. In pregnancy, it may rarely cause _____ anomoly, in which the fetus has a cardiac valvular defect.
Lithium
0.6 - 1
Kidney disease
Nephrotoxicity
Ebtein’s anomoly
_______ acid is another Mood Stabilizer used to treat all three phases of Bipolar disorder. It’s side effects include _______toxicity, Thrombocytopenia, _______ ovarian syndrome, Pancreatitis, and more.
Valproic Acid
Hepatotoxicity
Polycystic Ovarian Syndrome
Carbamazepine is a mood stabilizer used for all three phases of Bipolar. It’s side effects include _______/hyponatremia, Leukopenia, Hepatotoxicity, and others.
Carbamazepine has significant drug-drug interactions bc it increases activity of ______ (which also increases its own metabolism/breakdown).
SIADH/hyponatremia
CYP450
