lecture 6 part 2 Flashcards
RNA polymerase
must be ______ by _________
activated, phosphorylation
Modification of the polymerase is done by the ____ ____
kinase TFIIH
modification of kinase TFIIH leads to a change
in
RNA pol II
conformation
RNAs can possess ______ ________ stems loops and folds
secondary structures –
processing of hnRNA (premRNA) will
involve
splicing, capping, poly A tail addition
In prokaryotes, one RNA can encode several proteins. This type of gene
organization is called an
operon.
what is is a major way eucaryotes manage to do a lot with relatively few genes.
Alternative splicing
Non-coding regions are removed from pre-mRNA transcripts by complexes containing
snRNAs
snRNPs bind to
specific sequences that
designate removal of the intron
snRNPs form a complex known as a __________
that removes the intron.
spliceosome
of post-transcriptional gene regulation by _____ can _____ ___ gene functions selectively.
double stranded siRNAs , knock down
___________also functions in regulating different genes by miRNAs encoded by the genome.
, RISC complex, tha
Amino acyl tRNA synthetases attach amino acids to their correct tRNAs via a
covalent bond.
tRNA synthetases uses ATP as
linkage of A.A ATP-> AMP+P P
Polyribosome =
1 mRNA plus several translating ribosomes
