Lecture 6: Integration of GP and triggering AP

Question 1

Integration of GP and triggering of AP occurs at

Answer 1

Axon hillock, where the change in membrane potential from the GP initiates the AP

Question 2

Threshold Potential

Answer 2

• the depolarization in MP that will open the sodium voltage gated channels
• this requires the GP reaching the axon hillock to be strong enough to open Na+ voltage gated channels at the hillock to generate the AP

Question 3

Integration of GPs

Answer 3

either a single large GP or multiple small GP combined can trigger APs

Question 4

Temporal Summation

Answer 4

GPs that occur at slightly different times that combined create a net change in Em that goes over the threshold potential

Question 5

Spatial Summation

Answer 5

GP from different locations that can create a net change in Em to induce an Ap
-ie. GPs occur from different dendrites

Question 6

Excitatory GP vs. Inhibitory GP

Answer 6

• Excitatory causes depolarization, bringing Em closer to threshold pot.
• Inhibitory causes hyperpolarization and brings Em away from Threshold Potentail