Lecture 6 - Genetic versus phenotypic adaptation

Question 1

Genotypic vs phenotypic evolution

Answer 1

Genetic:
* Heritable
* Relatively slow
* Transition to new population type
* Constant environmental stress

Phenotypic:
* Not heritable
* Fast
* Perseverance and recovery
* Fluctuating environments

Question 2

Pharmacokinetics: what is it and what are the steps of it?

Answer 2

The movement and modification of medicine through the body

1 - absorption
2 - distribution
3 - metabolism
4 - excretion

Question 3

Resistant vs persistent survivals with ABs

Answer 3

Low AB concentrations:
Resistant survive and thrive

High AB concentrations:
Persistents survive and thrive

Question 4

Resistant vs persistent survivals with number of cells

Answer 4

Low cell number:
Persistents survive and thrive

High cell number:
Resistant survive and thrive

Question 5

Why are persisters bad?

Answer 5

Persisters can lead to ‘hidden’ treatment failure and infection relapse

Question 6

Genetic phage resistance

Answer 6

phage receptors