Lecture 6 - Arrangement of different embryo cells in space

Question 1

What is a morphogen?

Answer 1

A molecule that defines two or more cell fates

at different concentrations

Question 2

What is the flag pole model?

Answer 2

• Flag pole makes a signal for the blue cells
• Blue cells makes a signal for the white cells
• White cells makes a signal for the red cells

Question 3

What is the role of the anchor cell in the development of the vulva in C.elegans?

Answer 3

Sends out signal causing vulva to be made from P5p, P6p, and P7p

Question 4

What happens if you destroy the anchor cell?

Answer 4

The vulva doesn’t develop

Question 5

True or False? Any cell from P3p to P8p can become the vulva

Answer 5

True

Question 6

What does the concentration of Lin-3 determine?

Answer 6

The primary and secondary cell fates

Question 7

What happens to a LIN-12 LOF mutant?

Answer 7

No secondary cells

Question 8

What happens to a LIN-12 GOF mutant?

Answer 8

Too many secondary cells

Question 9

What is Lin-12?

Answer 9

A receptor

Question 10

What signals from the primary is needed to activate Lin-12?

Answer 10

• Apx1
• Lag2
• Dsl1

Question 11

What cell does Lin-3 drive towards?

Answer 11

Primary cell

Question 12

What cell does Lin-12 drive towards?

Answer 12

Secondary cell

Question 13

What is the relationship between Lin-3 and Lin-12?

Answer 13

Lin-3 signalling regulates Lin-12 expression

Question 14

What is Morphogenesis?

Answer 14

Taking on a new shape

Question 15

What happens during to the mesoderm in Drosophila?

Answer 15

• Needs to be inside

- Moved inside via invagination

Question 16

How do the cells change during dorsal closure in Drosophila?

Answer 16

• The cells get slightly wider and a lot longer

- Increases surface area

Question 17

What is Epiboly?

Answer 17

When two different layers merge together to make one

Question 18

What is Convergence extension ?

Answer 18

• Movement between one layer

- The cells move towards each other forming a line