Lecture 6 Flashcards

1
Q

Enteral Nutrition
Related
Complications

A
GI
Metabolic,
pulmonary
fluid status
mechanical
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2
Q

Gastrointestinal EN-Related Complications

A
Nausea and vomiting
– Occurs in 7-26% of patients on EN
• Increased risk of aspiration
– Possible etiologies
• Delayed gastric emptying / gastroparesis
• Hypotension, hemodynamic instability
• Stress, sepsis
• Anesthesia / surgery
• Medications (i.e. narcotics, sedation)
• Very cold enteral formula
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3
Q

Gastrointestinal EN-Related Complications

Interventions

A
Interventions
ü Change EN formula
• Low-fibre, low-fat
ü Temporarily reduce the
formula infusion rate
ü If applicable, change feeding
modality (i.e. from bolus to
intermittent or continuous
ü Use room temp feeds
ü Liase with team re meds:
• Reassess narcotics
• Prokinetic agent?
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4
Q

Prokinetic Agents

A
• “Prokinetic” = promote movement
• Drugs that enhance GI motility
– Various mechanisms of action
• Stimulate gut motility, esophageal peristalsis, strengthen lower esophageal
sphincter pressure to promote gastric emptying
• Common prokinetic agents in Canada
– Metclopromide (Maxeran®)
– Domperidone
– Erythromycin (antibiotic)
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5
Q

Gastrointestinal EN-Related Complications

A
Abdominal distension
– GI ileus
– Bowel obstruction
– Constipation / obstipation
– Ascites
– Initial use of high fibre feed
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6
Q

Gastrointestinal EN-Related Complications Abdominal distension

Interventions

A
ü Testing to r/o (rule out)obstruction or ileus
• Imaging
• Abdominal x-ray
• CT
ü Hold feeds if necessary
• Not necessary if intestinal
appearance/function are normal
and patient not experiencing pain
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7
Q

Gastrointestinal EN-Related Complications

Malabsorption

A
– Signs and symptoms (s/s)
• Weight loss
• Steatorrhea
• Diarrhea
– Disease related
• IBD (Crohn’s, Colitis)
• Radiation enteritis
• Enteric fistulas
• Pancreatic insufficiency
• Short bowel syndrome
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8
Q

Gastrointestinal EN-Related Complications
Malabsorption
Interventions

A

Interventions
ü Trial (semi) elemental formula
ü (Supplemental) PN if
unresponsive to EN

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9
Q

Gastrointestinal EN-Related Complications

Diarrhea

A
Incomplete absorption of fluid and electrolytes from lumen of GIT
– No true definition
• Abnormal volume & consistency
• >500 mL/24h
• 3 loose stools/d x 2d
– Etiologies
• Drugs
• Disease, infection
• Feeding formulas
– Hyperosmolar
– Lactose containing
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10
Q

Types of Diarrhea

5

A
Secretory
• Caused by
abnormal ion
transport in
intestinal
epithelial cells
resulting in
decreased
electrolyte
absorption
Osmotic
• Excess amounts
of poorly
absorbed
substances
remain in GIT
which obligate
water retention
2o to osm
Malabsorption
• Conditions
resulting in
malabsorption
of nutrients
Inflammatory
• Inflammatory
bowel diseases
• Infectious
etiologies (i.e.
C.diff)
Disordered
Motility
• Diabetic
neuropathy
• Irritable
bowel
syndrome
• Postvagotomy
etc.
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11
Q

Conditions Associated with Secretory Diarrhea

A
• Clostridium difficile infection
• Intestinal resection
• Inflammatory bowel disease
• Bile acid malabsorption
• Chronic infections
• Celiac sprue
• Small intestinal lymphoma
• Villous adenoma of the
rectum
• Zollinger-Ellison syndrome
• Collagen vascular diseases
• Congenital defects
• Malignant carcinoid
syndrome
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12
Q

Enteral Formula

A
Hyperosmolar formulas
– What types of formulas tend to be hyperosmotic?
• Components of formulas or modulars
– Lactose
– Read the ingredients!
– Clinical observation
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13
Q

Managing Diarrhea: Other Nutrition Strategies

A
• Change formula type
– Intact protein à peptides
• Add soluble or insoluble fibre
– Change EN formula
– Fibre modular (i.e. Benefibre®)
– Metamucil, pectin
• Consider PN if warranted
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14
Q

Gastrointestinal EN-Related Complications

A
Constipation
– Also difficult to define
• Physical s/s
• Imaging (Abdo XR)
– Common causes
• Dehydration
• Inadequate/excessive fibre
• Medications
• Immobilization
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15
Q

Gastrointestinal EN-Related Complications
Constipation
Interventions

A
Interventions
ü Ensure adequate hydration
ü Switch to formula with fibre
ü Ensure patient is on a “bowel
routine” (i.e. medications prn)
ü Mobilize patient
• “Mobility = motility”
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16
Q

Pulmonary EN-Related Complications Pulmonary

• Pulmonary aspiration

A
– Definition: Inhalation of material
into the airway
• EN-related concern
– Inhalation of gastric contents/feed
into airway
– Aspiration pneumonia
17
Q

• Pulmonary aspiration

Management Strategies

A
Tube placement confirmed
radiologically
• Chest x-ray (CXR) NG tubes
• Abdo x-ray G/J-tubes
ü HOB > 30-45 degrees while feeding
ü Manage nausea and vomiting
ü Gastric residual volumes (GRV’s)
• Controversial!
18
Q

Hydration Fluid Considerations with EN

A
• Avoid dehydration
– Patient’s on EN at high risk
– EN feed alone won’t provide sufficient
fluid/free water
• Water flushes
• “Ins and outs”
– Ins: IV’s, EN, free water, medications
– Outs:
• Urine, stool, “insensible losses”
• Disease: ostomy, fistula, drains, paracentesis etc.
19
Q

Hydration Fluid Considerations with EN

Management Strategies

A
Management Strategies
ü Physical assessment to detect
ü Laboratory findings to detect
ü Assess “ins and outs”
ü Include fluids/water in your EN
calculations
20
Q

Mechanical Complications Associated with EN

Tube blockage

A

– Inadequate flushing

– Large amounts of crushed meds, modulars going into tube

21
Q

Tube blockage

Management Strategies

A

ü Routine water flushes (minimum 25-30 cc q4h)
ü Tube unclogging protocol: pancrealipase / NaHCO3 mixture
• DO NOT USE: coke, cranberry juice etc.
ü Tube change may be required

22
Q

Mechanical Complications Associated with EN

Irritation from Feeding Tube

A
– Sinusitis from NGT/OGT
– Nose bleeds
– ? Swallowing dysfunction with NGT
in situ
– Leakage or wound infection
(PEG/PEJ)
23
Q

Irritation from Feeding Tube

Management Strategies

A

ü Proper tube/wound care

ü Tube changes as needed

24
Q

Specific Drug-Enteral Nutrition Interactions

A

Indications that drug bioavailability is reduced when administered
with EN formula for the following:
– Phenytoin (Dilantin®) (anti-seizure medication)
– Fluoroquinolone antibiotics
• Ciprofloxacin, Levoflaxcin, Ofloxacin
– Levothyroxine (Synthroid®) (for hypothyroidism)
• Very controversial
• Management
– Hold enteral feed 2h pre/post drug administration
– Change to IV