Lecture 6 Flashcards
Define somatic sensation
Sensation from body tissues
Define somatic sensation
Sensation from body tissues
What does fibre Aalpha sense?
Motor and somatic proprioception
What do Abeta nerve fibres sense?
Touch pressure
What do Adelta nerve fibres sense?
Pain and temperature
What do Agamma nerve fibres sense?
Motor spindles
What do B nerves do?
they are pregangionic sympathetic neurons
What do C fibres sense?
Pain and they are the post-ganglionic sympathetic neurons
Which type of nerve fibre is responsible for touch pressure?
Abeta (II)
Which type of nerve fibre is responsible for motor and somatic proprioception?
A alpha (I)
Which type of nerve fibre is responsible for pain and temperature?
A delta (III)
Which type of nerve fibre is responsible for motor spindles?
A gamma
Which type of nerve fibre is pre-ganglionic sympathetic?
B
Which type of nerve fibre is responsible for pain and is post-ganglionic sympathetic?
C (IV)
Which type of nerve fibre is unmyelinated?
C
Why are there 2 sets of pain fibres?
A delta mediates sinal reflexes such as the withdrawal reflex
C nerves become more sensitive when the tissue is damaged
What neurons are involved in skin innervation?
Meissner’s corpuscle detects steady pressure
Bare nerve ending detects pain
Pacininian corpuscle detects vibration
Merkel’s receptor detects pressure
What is the threshold for cold pain and which nerve fibre detects it?
What is the threshold for hot pain and which nerve fibre detects it?
> 46C if held and type C
>52C would to reflexively pulling away and both type C and Adelta
Give an example of a rapidly adapting neuron
Pacinian corpuscle
Give an example of a slowly adapting corpuscle
Merkel Cell
What do prostaglandins mediate?
Primary hyperalgesia
List some common inflammatory mediators
Prostaglandins Bradykinin 5-HT receptor Histamine Purines Neuropeptides
What are the main sources of inflammatory mediators?
Leukocytes
Mast cells release histamine
What are the main sources of inflammatory mediators?
Leukocytes
Mast cells release histamine
What does fibre Aalpha sense?
Motor and somatic proprioception
What do Abeta nerve fibres sense?
Touch pressure
What do Adelta nerve fibres sense?
Pain and temperature
What do Agamma nerve fibres sense?
Motor spindles
What do B nerves do?
they are pregangionic sympathetic neurons
What do C fibres sense?
Pain and they are the post-ganglionic sympathetic neurons
Which type of nerve fibre is responsible for touch pressure?
Abeta (II)
Which type of nerve fibre is responsible for motor and somatic proprioception?
A alpha (I)
Which type of nerve fibre is responsible for pain and temperature?
A delta (III)
Which type of nerve fibre is responsible for motor spindles?
A gamma
Which type of nerve fibre is pre-ganglionic sympathetic?
B
Which type of nerve fibre is responsible for pain and is post-ganglionic sympathetic?
C (IV)
Which type of nerve fibre is unmyelinated?
C
Why are there 2 sets of pain fibres?
A delta mediates sinal reflexes such as the withdrawal reflex
C nerves become more sensitive when the tissue is damaged
What neurons are involved in skin innervation?
Meissner’s corpuscle detects steady pressure
Bare nerve ending detects pain
Pacininian corpuscle detects vibration
Merkel’s receptor detects pressure
What is the threshold for cold pain and which nerve fibre detects it?
What is the threshold for hot pain and which nerve fibre detects it?
> 46C if held and type C
>52C would to reflexively pulling away and both type C and Adelta
Give an example of a rapidly adapting neuron
Pacinian corpuscle
Give an example of a slowly adapting corpuscle
Merkel Cell
What do prostaglandins mediate?
Primary hyperalgesia
List some common inflammatory mediators
Prostaglandins Bradykinin 5-HT receptor Histamine Purines Neuropeptides
Which receptors detect thermal pain?
TRPV1 - Aching
TRPV2 - Reflex
What are the main sources of inflammatory mediators?
Leukocytes
Mast cells release histamine
What are the two roles of prostaglandins?
Senstitisation e.g. PGE2
Excitation e.g. PGI2
What are NSAIDs?
Non-steroidal anti-inflammatory drugs e.g. ibruprofen and voltarol which work by inhibiting Cox-1 and Cox-2
What are the 5 spinal regions?
Cervical Region 8 segments Thoracic Region 12 segments Lumbar Region 5 segments Sacral Region 5 segments Coccygeal 3 segments