Lecture 5 - Pathophysiology of RBC

Question 1

Life span of RBC

Answer 1

120 days

Question 2

RBCs destroyed where?

Answer 2

spleen and liver

Question 3

What happens to the globulin, lipids, and hemoglobin of RBCs when recycled?

Answer 3

globulin - converted to amino acids

lipids - recycled

hemoglobin - heme metabolized, iron recycled, remaining converted to bilirubin

Question 4

When bilirubin binds to albumin

Answer 4

it is free, or unconjugated

taken up by liver cells

conjugated to make more water soluble

then excreted into bile

Question 5

What causes excess bilirubin?

Answer 5

too much RBC destruction (hemolytic anemia)
dec hepatic uptake (hepatitis, cirrhosis)
dec conjugation (hepatitis, cirrhosis)
dec secretion into bile (hepatitis, cirrhosis)
bile duct obstruction (tumor, gal stone)

Question 6

if dark feces….

Answer 6

hemolytic anemia

Question 7

Normal total RBC count

Answer 7

4.2-6.2 million per microL

Question 8

Normal reticulocyte count

Answer 8

1% of RBCs

Question 9

manifestations of polycythemia

Answer 9

liver/spleen have build up of RBCs
thick blood
headaches, vertigo, light-headedness
too many cells in bone marrow

Question 10

manifestations of anemia

Answer 10

lack of color in skin, nail beds, and mucous membrane

decreased RBCs in blood

Question 11

cytic deals with…

Answer 11

size of cells

Question 12

chomic deals with

Answer 12

hemoglobin content

Question 13

Normal hematocrit in men

Answer 13

42-54%

Question 14

Normal hematocrit in women

Answer 14

38-46%

Question 15

What does it mean if urine is dark?

Answer 15

liver is conjugating bilirubin