Lecture 5 Immunotherapy

Question 1

What vascular changes occur during hyper-acute rejection

Answer 1

Complement activation
Endothelial damage
Inflammation
Thrombosis

Question 2

What vascular changes occur during acute rejction

Answer 2

Parenchymal damage
Interstitial inflammation
Endotheliatitis

Question 3

What vascular changes occur during chronic rejection

Answer 3

Chronic inflammatory reaction in vessel wall
Intimal smooth muscle cell proliferation
Vessel occlusion

Question 4

Name licensed indications for IVIg

Answer 4

Primary immunodeficiency 
Idiopathic Thrombocytopenic Purpura
Kawasaki disease
Children with HIV
Multiple myeloma/CLL

Question 5

Name 3 examples of direct immunotherapy

Answer 5

Monoclonal antibodies
Chimeric antigen receptors
Bi-specific antibodies

Question 6

Are Tumour factors direct or indirect immunotherapy

Answer 6

Indirect

Question 7

What is the first line treatment for non-Hodgkin’s Lymphoma

Answer 7

Rituximab

Question 8

Anti-TNF therapy Infliximab is used to treat what kind of disease

Answer 8

Autoimmune
Ankylosing spondylitis
Crohn's disease
Ulcerative colitis
RA

Question 9

What are checkpoint inhibitors

Answer 9

Unlock the gateway to the adaptive immune system

Powerful anti-tumour responses

Question 10

How do tumour cells inhibit T cell killing

Answer 10

PDL-1 on the tumour cell binds to PD-1 on the T cell and inhibits T cell killing of the tumour cell

Question 11

What is CAR T Cell Therapy

Answer 11

T cell engineered to express antigen-targeted receptors specific for tumour antigens