Lecture 3 Autoimmunity Flashcards
What is immunological tolerance
Unresponsiveness to an antigen that is induced by previous exposure
What is Central Tolerance
Thymus eliminates T cells with high affinity to self-antigens
What is Peripheral Tolerance
Mature lymphocytes that recognise self-antigens in peripheral tissues become incapable of activation or die by apoptosis
Define Anergy
Functional unresponsiveness
What is autoimmunity
Adaptive responses to self-antigens
What causes autoimmune disease
Autorecative T cels or auto antibodies cause tissue damage through hypersensitivity reactions II, III and IV
What is molecular mimicry
Structural similarity between self-proteins and microbial antigens. Which can trigger and autoimmune response
Group A streptococcal M protein has a similar structure to ____ which can lead to what disease
Antigen on cardiac muscle
Rheumatic fever
Bacterial heat shock proteins have a similar structure to_____ which can lead to what disease
Self-heat shock protein
several autoimmune diseases (non proven)
Coxsackie B4 nuclear protein has a similar structure to ___which can lead to what disease
Pancreatic islet cell, glutamate, decarboxylase
Insulin dependent DM
Campylobacter has a similar structure to____which can lead to what disease
Myelin-associated gangliosides and glycolipids
Guillain-Barre syndromw
Name 4 non-organ specific types of autoimmune disease
SLE
Scleroderma
RA
Dermatomyositis
