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Immunology > Lecture 2 Hypersensitivity > Flashcards

Lecture 2 Hypersensitivity Flashcards

1
Q

How can influenza cause hypersensitivity

A

Virus damages epithelial cells in respiratory tract triggering cytokine storm

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2
Q

What is the adaptive immune system mediator involved in type 1 hypersensitivity

A

IgE

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3
Q

What are the innate immune system mediators in type 1 hypersensitivity

A

Mast cells

Eosinophils

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4
Q

What is the adaptive immune system mediator involved in type 2 hypersensitivity

A

IgG

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5
Q

What are the innate immune system mediators in type 2 hypersensitivity

A

Complement

Phagocytes

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6
Q

What are the adaptive immune system mediators in type 3 hypersensitivity

A

IgG

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7
Q

What is the innate immune system mediators in type 3 hypersensitivity

A

Complement

Neutrophils

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8
Q

What are the adaptive immune system mediators in type 4 hypersensitivity

A

T cells

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9
Q

What is the innate immune system mediator in type 4 hypersensitivity

A

Macrophages

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10
Q

What type of genetic defect leads to 50% of severe eczema

A

Polymorphism in filggarin which is expressed by keratinocytes and is involved in maintaining the epithelial barrier, moisturising surfaces and controlling pH

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11
Q

What do Mast ells produce during anaphylaxis and what is the effect

A

Prostaglandins and Leukotrienes

Vasodilation and increased vascular permeability

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12
Q

Name 4 drug treatments for anaphylaxis

A

B2-adrenergic agonist (Salbutamol)
Epinephrine (adrenaline)
Antihistamines
Corticosteroid

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13
Q

What type of hypersensitivity is immune mediated haemolysis

A

Type 2

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14
Q

What antibodies are involved in type 2 hypersensitivity

A

IgG and IgM

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15
Q

Which antibodies are responsible for type 3 hypersensitivity

A

IgG

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16
Q

What are immune complexes in hypersensitivity type 3

A

Formed by antigen and antibody and cause damage at the site of production or circulate and cause damage elsewhere

17
Q

What are common diseases caused by type 3 hypersensitivity in the kidney

A

Glomerulonephritis (post streptococcal)
Nephrotic syndrome
Nephritis

18
Q

Which hypersensitivity is the slowest out of the 4

A

Type 4

19
Q

Name diseases that are caused by type 4 hypersensitivity

A 
RA
Multiple sclerosis
Type 1 diabetes 
celiac disease
Contact dermatitis

Immunology (5 decks)

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