Lecture 2 Hypersensitivity Flashcards
How can influenza cause hypersensitivity
Virus damages epithelial cells in respiratory tract triggering cytokine storm
What is the adaptive immune system mediator involved in type 1 hypersensitivity
IgE
What are the innate immune system mediators in type 1 hypersensitivity
Mast cells
Eosinophils
What is the adaptive immune system mediator involved in type 2 hypersensitivity
IgG
What are the innate immune system mediators in type 2 hypersensitivity
Complement
Phagocytes
What are the adaptive immune system mediators in type 3 hypersensitivity
IgG
What is the innate immune system mediators in type 3 hypersensitivity
Complement
Neutrophils
What are the adaptive immune system mediators in type 4 hypersensitivity
T cells
What is the innate immune system mediator in type 4 hypersensitivity
Macrophages
What type of genetic defect leads to 50% of severe eczema
Polymorphism in filggarin which is expressed by keratinocytes and is involved in maintaining the epithelial barrier, moisturising surfaces and controlling pH
What do Mast ells produce during anaphylaxis and what is the effect
Prostaglandins and Leukotrienes
Vasodilation and increased vascular permeability
Name 4 drug treatments for anaphylaxis
B2-adrenergic agonist (Salbutamol)
Epinephrine (adrenaline)
Antihistamines
Corticosteroid
What type of hypersensitivity is immune mediated haemolysis
Type 2
What antibodies are involved in type 2 hypersensitivity
IgG and IgM
Which antibodies are responsible for type 3 hypersensitivity
IgG
What are immune complexes in hypersensitivity type 3
Formed by antigen and antibody and cause damage at the site of production or circulate and cause damage elsewhere
What are common diseases caused by type 3 hypersensitivity in the kidney
Glomerulonephritis (post streptococcal)
Nephrotic syndrome
Nephritis
Which hypersensitivity is the slowest out of the 4
Type 4
Name diseases that are caused by type 4 hypersensitivity
RA Multiple sclerosis Type 1 diabetes celiac disease Contact dermatitis
