Lecture 5: Applied Transfusion Flashcards
What is the main blood grouping? What types can be made from it?
ABO, with the types being:
- A
- B
- AB
- O
Why is O so prevalent in the population despite it being recessive?
Because
What is the most common to least common blood groups in ABO system?
O, then A, then B, then AB
What specific antigens are present in ABO blood grouping system?
O - Chain of carbohydrates, galactose, then N acetyl-glucosamine, then galactose, then fucose.
A - Galactose, then N acetyl-glucosamine, then galactose, then fucose, also bonded to second galactose is N acetyl-galactosamine.
B - Galactose, then N acetyl-glucosamine, then galactose, then fucose, also bonded to second galactose is a third galactose
AB - Displays both the A and B types.
What types of A blood group are there?
What is the Rh blood group system?
An antigen system that consists of around 50 antigens. The most important of which are:
- D
- C
- c
- E
- e
You can either have these antigens or be negative.
What genes control the presence of Rh groups? Which is the most important?
RHD and RHCE.
RHD being the most significant.
Why is RhD the most important Rh group?
Because it is the most immunogenic antigen behind ABO grouping.
What is haemolytic disease of the newborn?
A
How does haemolytic disease of the newborn occur?
What is the Kleihauer test?
It is a test that exploits the difference in acid tolerance between foetal haemoglobin and adult.
The test involves the
What drugs are available to treat haemolytic disease of the newborn? How does it work?
How do you perform an antibody screen?
