Lecture 5 - Anatomy Flashcards
What are the four layers of the gut tube?
Mucosa
Submucosa
External muscle layers
Serosa
Describe the layers of mucosa in the gut tube
- epithelial layer: promote absorption, hormones and mucus
- lamina propria: lymphoid nodules and macrophages and produces antibodies
- muscularis mucosae: smooth muscle in different function, keeps contents dynamic to prevent inflammation
Describe the submucosal layer
Dense CT, blood vessels, glands
Contains submucosal plexus
Describe the external muscle layers
Inner circular muscle
Outer longitudinal muscle
Myenteric plexus in between
Describe the serosal layer
Blood, lymph and adipose
Continuous with mesenteries
What is the epithelium in the oesophagus and distal anus?
Stratified squamous to resist frictional forces
Which type of epithelium lines the rest of the GI tract?
Simple columnar (for secretion and absorption)
What are the types of specialised cells in the GI tract?
Enterocyte
Goblet cell
Foveolar cells
Describe enterocytes
Simple columnar epithelial cells for absorption
In SI and colon
Microvilli forms brush border
Describe goblet cells
Between enterocytes
Mucus protects epithelia from friction, chemical damage and bacterial inflammation
Describe foveolar cells
Secrete mucus/HCO3- that forms barrier to stomach acid
What are the permanent folds of the small intestine called?
Plicae circulares
What are the temporary folds of the stomach called and what are they needed for?
Rugae
Stomach needs to expand easily to prevent reflux into oesophagus
What is the difference between villi and crypts?
Villi in SI, not colon
Crypts in both SI and LI
Which cells do the crypts of Lieberkuhn contain?
Stem cells
Paneth cells
Enteroendocrine cells
What is the function of the stem cells in the crypts?
Constantly divide every 2-4 days to replace epithelia