Lecture 5 Flashcards
(123 cards)
Adrenergic Agonists are also called: (3)
Adrenoceptor Agonits
Sympathomimetics
Fight and flight
____ is the main SNS neurotransmitter.
Norepinephrine
Norepinephrine (noradrenaline), epinephrine (adrenaline), dopamine, and dobutamine are referred to as ________.
Catecholamines
____ is released from the adrenal medulla when stimulated by the SNS as a hormone.
Epinephrine
6 steps of norepinephrine:
1) Synthesis of norepi
2) Uptake into storage vesicles
3) Release of neurotransmitter
4) Binds to receptor
5) Removal of norepi
6) Metabolism
Norepinephrine is the main ___ neurotransmitter.
SNS
1) ____ is transported intracellularly and hydroxylated into dihydro-Phenoxyalanine (DOPA).
Tyrosine
Which step is the rate-limiting step of norepinephrine?
Synthesis (tyrosine to DOPA)
1) DOPA is then decarboxylated into ____.
Dopamine
2) Dopamine is transported into vesicles where some/most of it is converted into _____.
Norepinephrine
Epinephrine is released from the _____ when stimulated by the SNS as a hormone.
Adrenal medulla
3) The action potential reaches the neuron, ____ rushes into the cell, and the vesicles fuse with the cell at the synaptic junction releasing norepinephrine into the synapse.
Calcium
4) Norepinephrine diffuses into the synapse and binds to _____.
Either pre or post synaptic receptor.
4)The presynaptic receptors provide a ____.
Feedback loop
4) The postsynaptic receptors _____.
Trigger a response by the effector cell.
Tyrosine is transported intracellularly and hydroxylated into _______.
Dihydro-Phenoxyalanine (DOPA)
What 4 drugs are catecholamines?
Norepinephrine (Noradrenaline)
Epinephrine (Adrenaline)
Dopamine
Dobutamine
Epinephrine is released from the adrenal medulla when stimulated by the SNS as a _____.
Hormone
4) The __-synaptic receptors provide a feedback loop.
Pre
Epinephrine is released from the adrenal medulla when stimulated by the ____ as a hormone.
SNS
4) The __-synaptic receptors trigger a response by the effector cell.
Post
5) What are the 3 ways norepinephrine is removed?
Diffuses away
Metabolized by catechol-O-methyl transferase (COMT) on the postsynaptic membrane
Presynaptic membrane reabsorbs the norepinephrine
What is the most common way norepinephrine is removed?
Presynaptic membrane reabsorbs the norepinephrinet
6) What two ways can norepinephrine be metabolized?
Reused by presynaptic neuron
Degraded by monoamine oxidase (MOA)