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HUBS MODULE 4 > Lecture 47: > Flashcards

Lecture 47: Flashcards

1
Q

What is humoral immunity?

A
  • immunity mediated by secreted antibodies

- —> involves B cells

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2
Q

What does humoral immunity protect you against?

A 
- extracellular pathogens
IgM - first antibody to be produced, - half life 4 days
IgG - half life 4 months
IgM & IgG = circulatory infections
IgA - mucosal infections
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3
Q

What does cell mediated immunity protect you against?

A
  • intracellular bacterial and virus infections
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4
Q

What is cell mediated immunity?

A

Immunity which involves T cells, macrophages and NK cells

  • –> protects you against acute and chronic intracellular infections
  • does NOT include antibodies
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5
Q

What is the response to acute intracellular pathogens?

- cell mediated immunity?

A

Cytotoxic t cells target antigens
- release of granules —–> cell apoptosis
granzymes activate apoptotic enzymes

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6
Q

What is the response to chronic intracellular pathogens?

A

T helper cells up regulate the function of macrophages and NK cells

  • —-> unregulated by cytokines
  • —–> increased phagocytosis of all pathogens
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HUBS MODULE 4 (11 decks)

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