Lecture 46 - Pathophysiology of Seizure Disorders Flashcards
Epilepsy Statistics
> 80% of all patients with epilepsy will experience their first seizure by the age of 20
Chance of recurrence:
– After a single seizure: 20%
– After a second seizure: 60%
– After a third seizure: 75%
Generalized seizures (non-absence types)
myoclonic
tonic
clonic
atonic
tonic-clonic
Myoclonic
- shock-like contraction of muscles
- isolated jerking of head, trunk, body
Tonic
- these seizures occur in children
- involve rigidity as a result of
increased tone in extensor muscles
Clonic
- these seizures occur in
babies and young children - involve rapid, repetitive motor activity
Atonic
- sudden loss of muscle tone
- patients fall if standing (‘drop attacks’)
Tonic-Clonic
- tonic phase immediately followed by clonic phase
- referred to as ‘grand mal’, characteristic of epilepsy
Seizure
paroxysmal disorder of the CNS characterized by abnormal cerebral neuronal discharges with or without loss of consciousness.
Paroxysm
sudden attack or outburst
Convulsion
specific seizure type where the attack is manifested by involuntary muscle contractions (this term is de-emphasized in the 2017 classification system).
Epilepsy
Repeated seizures due to damage, irritation, and/or chemical imbalance in the brain which leads to a sudden, excessive, synchronous electrical discharge.
Seizures involve
the anomalous firing of a population of neurons in the brain.
A seizure originates from
the gray matter of any cortical or subcortical area of the brain.
Seizures are a result of
disordered, synchronous, and rhythmic firing of a population of brain neurons (synchronized hyperexcitability).
Neurons recruit adjoining neurons to do the same.
* The clinical manifestations depend on the site of the focus, on the degree of irritability of the surrounding area of the brain, and on the intensity of the impulse.
* During a seizure, the brain uses more energy than it can manufacture (and more O2), and thus prolonged seizures can result in cell ischemia.
Seizure classifications
focal onset
generalized onset
unknown onset