Lecture 4.5 Beta Adrenergic agonists Flashcards
Isoproterenol is a (Selective/non-selective) beta receptor agonist. It causes broncho_____ and _____ cardiac output
non-selective (ie beta 1 and 2)
dilation and increased
isoproterenol (is/is not) sensitive to MAO and thus has a _____ duration of action
is not;
long
At high doses, B2 selective agonists may show ____ effects
cardiac
______ is a b2 selective agonist that is used to prevent premature labor (aka __lytic)
terbutaline, tocolytic
metaproterenol is a ____ receptor agonist that causes broncho____ . it is used to treat ____
beta 2, dilation, asthma (and COPD)
____ is a beta 2 receptor agonist used for short-term asthma.
albuterol (also levalbuterol)
____ is a beta _ receptor agonist that has a longer duration of action and is used more in long-term asthma or COPD
SALMETREROL, 2
_____ is a long acting beta 2 receptor agonist that as quicker onset of action than salmeterol. Neither are metabolized by ___ or ___
formoterol;
MAO, COMT
Dobutamine is a ____ mixture. The positive enantiomer is a B_ receptor agonist and an alpha 1 receptor ____.
The negative enantiomer is a alpha 1 receptor ___
racemic;
1, antagonist;
agonist
Overall, the net effect of dobutamine is a positive ____ effect on the heart with little ____ effect. It is used in acute _____
inotropic, chronotopic;
heart failure
____ works by displacing NT from vesicles and stimulating release of NE
amphetamine
_____ works by blocking the NE transporter and preventing re-uptake
cocaine
Besides amphetamine and cocaine, name 3 other indirect-acting sympathomimetics:
they promote the release of NE by _____ ____ of the plasma embrane transporter
pseudophedrine, ephedrine, tyramine
reverse action
clinical uses of indirect acting sympathomimetics:
narcolepsy, obesity, ADHD
pseudoephedrine vs ephedrine:
____’s major mechanism of action is reversal of the transporter. ____’s major mechanism of action is direct agonist activity at adrenergic receptors
psuedoephedrine;
ephedrine
