Lecture 4: Viruses Flashcards
- What virus is this?
- What is the vaccine?
- What are the characteristics of the vaccine?
- Human Papilloma Virus
- Causes cervical cancer and warts
- Gardasil
- Virus-like particle vaccine
- Vaccine has a capsid but no genome in it so can’t infect people
Overall definition of viruses
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Obligate, intracellular parasites
They’re acellular, non-living microbes that must infect a living cell in order to replicate. Depend on the host’s metabolism
What is a Virion (Veer E on)
Complete virus particle
What is a capsid?
Protein coat around a genome
What is a nucleocapsid?
Nucleic acid + capside
This is a picture of a nucleocapsid. Since it is a naked virus (no envelope) it also could be called a virion
What is a protomer?
Protein subunit of a capsid
What viral morphological shape is this?
Icosahedral
What viral morphological shape is this?
helical
What viral morphological shape is this?
Enveloped
What viral morphological shape is this?
Binal
What is this a picture of?
What do the numbers stand for?
1, red subunits are the nucelic acid (RNA in this instance)
Helical capsid
What virus is this?
What is its morphological shape?
Describe its nucleic acid:
Influenza
Enveloped virus with surface spoke proteins
****segmented RNA genome
Describe an icosahedral capsule:
Each ring shaped unit is called a ________. This is made from 5 or 6 __________
An icosahedral capsid is a common viral capsid shape as it is a very effiicient use of space. It has 20 triangular faces.
Each ring shapred unit is called a capsomer.
Each capsomer is made from 5 or 6 protomers (protein subunits of capsids)
What is complex viral symmetry?
Complex viral symmetry is ovid or brick shaped viruses that don’t fall into typical icosahedral, helical, binal or enveloped structures
In an enveloped virus, where do the spike proteins come from?
Where does the envelope come from?
Spike proteins are encoded by the virus itself
The envelope however of an enveloped virus is from the host cell membrane
