Lecture 4 Protein Structure

Question 1

Peptide bond Primary

Answer 1

When there is a linear line of

Question 2

Peptide bond secondary

Answer 2

Alpha and beta

Question 3

Peptide bond tertiary

Answer 3

Final fold form
usually due to the hydrophobic effect fold in this fashion so non polar resdiues on the inner and polar on the inner

Single peptide chain

Question 4

Quaternary structure

Answer 4

Comprised of more than one polypeptide chain
Can be a dimmer trimer or tetramers etc

Question 5

Coiled coiled

Answer 5

2alpha helices

Question 6

Parallel and Anti-Parallel

Answer 6

Parallel: same direction

Anti: opposite

Question 7

Beta Sheets

Answer 7

Can run Parallel or anti parallel
found in center of gobbler proteins

Question 8

Domain

Answer 8

A stable and compactly fold structure that is built from combination of secondary structures

Question 9

Understand the importance protein structure and function in relation to DZ

Answer 9

Prion DZ when the B were improperly folded and can file properly folded A and leads to down stream effects

Question 10

Describe the levels of protein structure and the role of H-Bonds in forming Secondary Structures and hydrophobic effect in relation to R groups

Answer 10

For tertiary structure the R groups that are non polar will go towards the center via hydrophobic effect