Lecture 4 - Is This Test Result Normal? Flashcards

1
Q

Clinical measurements yield 3 kinds of data. What are they?

A
  • Nominal
  • Ordinal
  • Interval
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2
Q

What is nominal data?

A

Categorical with NO inherent order

eg: blood groups O, A, B, AB
eg: dead/alive, male/female (dichotomous)

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3
Q

What is ordinal data?

A

Inherent ordering but size of intervals between categories NOT specific

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4
Q

What is interval data?

A

Inherent ordering and interval between successive values is equal

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5
Q

What are two types of interval data?

A
  1. Continuous (weight, blood glucose)

2. Discrete (number of pregnancies)

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6
Q

Define mode

A

The most commonly observed value

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7
Q

Define median

A

The middle observation (50th centile)

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8
Q

Define mean

A

The average value, or sum of all values divided by total no. of observations

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9
Q

What does standard deviation measure?

A

Average distances that observations are located from the mean, derived from variance

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10
Q

What is the distribution of +/- 1 SDs?

A

68.2%

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11
Q

What is the distribution of +/- 2 SDs?

A

95.45%

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12
Q

How many standard deviations are in the normal range?

A

2

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13
Q

What is “normal range” most commonly defined as?

A

95% of non-diseased

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14
Q

Define validity

A

The degree to which the data measure what they were intended to measure (aka accuracy)

eg. calibration of lab instruments might ensure valid measurements

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15
Q

Define reliability

A

the extent to which repeated measurements get similar results (aka reproducibility and precision)

eg. repeated measurements of BP on different observers are ways to assess reliability

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16
Q

What is regression to the mean?

A

Tendency for abnormal results, when repeated, to move closer to the average

17
Q

What are the requirements of regression to the mean?

A
  • Measurements vary from occasion to occasion
  • The person is selected on the basis of a high (or low) measurement
  • Original group = mixture of (a) ‘change high’ individuals & (b) ‘truly abnormal’ individuals