Lecture 4 - Biopharmaceutics

Question 1

What 5 factors is biopharmaceutics dependent on?

Answer 1

1) Chemical nature
2) Physical state
3) Type of dosage form
4) Presence/absence of excipients
5) Pharmaceutical process

Question 2

Define pharmacokinetics

Answer 2

Study and characterization of the time course of drug absorption, distribution, metabolism, and excretion (ADME)

Question 3

Define biopharmaceutics

Answer 3

Relationship between the physical and chemical properties of a drug in a dosage form and the pharmacologic response after administration

Question 4

What is clinical pharmacokinetics?

Answer 4

The application of pharmacokinetic methods in drug therapy

Question 5

Define pharmacodynamics

Answer 5

The relationship between drug concentration at the site of action and pharmacologic response

Question 6

Define bioavailability

Answer 6

The rate and extent (amount) to which a drug is absorbed from a drug product into the body or site of action

Question 7

What must first happen to protein-bound drugs?

Answer 7

They must dissociate

Question 8

What 2 things occur prior to absorption?

Answer 8

Dissolution & disintegration

Question 9

How must proteins be administered and why?

Answer 9

IV because they cannot be absorb in gut

Question 10

What are responsible for drug uptake?

Answer 10

Transporters

Question 11

What model describes most clinically used drugs?

Answer 11

One compartment open model