Lecture 4 - Anemia cases/FA things

Question 1

what anemia is associated with increased methylmalonic acid? what kind of anemia dues this cause?

Answer 1

B12 deficiency; megaloblastic anemi

Question 2

what does an absolute reticulocyte count greater than 100,000 indicate?

Answer 2

problem with shortened RBC survival

Question 3

first line treatment for autoimmune hemolytic anemia?

Answer 3

corticosteroids (to suppress Ig production)

Question 4

parvo-virus B19 infects ____ cells and is an important cause of ____

Answer 4

erythroid progenitor; aplastic anemia

Question 5

in an older male patient with iron deficiency anemia, what should be on the top of your list of causes?

Answer 5

GI bleed from cancer

Question 6

what disease is the schilling test used for?

Answer 6

B12 deficiency

Question 7

hemolysis leads to increased ____, reticulocytes, _____ bilirubin, and ____ in urine

Answer 7

LDH, unconjugated, urobilinogen

Question 8

name 3 v important findings in INTRAVASCULAR hemolysis:

Answer 8

decreased haptoglobin, hemoglobinuria, hemosiderinuria

Question 9

which form of hemolysis is more characterized by hepatosplenomegaly and bilirubin gallstones?

Answer 9

extravascular forms

Question 10

hereditary spherocytosis is characterized by increased ____, increased _____. what diagnostic test is used for it?

Answer 10

MCHC, RDW; osmotic fragility test

Question 11

most common cause of hemolysis in G6PD deficiency?

2 characteristic findings on peripheral smear

Answer 11

infection;

Heinz bodies (precipitated Hb) + bite cells

Question 12

PNH:
what does it show on flow cytometry?
most common cause of death?
_____ may occur days after hemolysis

Answer 12

CD55/59 NEGATIVE;

venous thrombosis;

hemosiderinuria

Question 13

what coomb’s test is this?

normal RBCs + patients serum + anti-human globulin

Answer 13

indirect