Lecture 4 - Amino acids and primary protein structure Flashcards
Zwitterion: what is it?
A molecule with a negative and positive side
What is the difference between L-amino acid forms and D-amino acid forms?
L-amino acids are used in protein synthesis and is an enantiomers of D-amino acids
Basic amino acid structure
H₂N-CH-COOH
\R
The basic structure of amino acids
H₂N-CH-COOH
\R
Glycine: R group, an interesting fact, shortened form, and what is the fully shortened form?
H
Gly
G
Alanine: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH₃
Ala
A
Valine: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH-CH₃
\CH₃
Val
V
Isoleucine: R group, an interesting fact, shortened form, and what is the fully shortened form?
H₃C-CH-CH₂-CH₃
Ile
I
Leucine: R group, an interesting fact, shortened form, and what is the fully shortened form?
R-CH₂-CH-CH₃-CH₃
Leu
L
Proline: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH₂-CH₂-CH₂-NH₂⁺
This forms a heterocycle within the amino acid where the R group binds with the amine group
Pro
P
Phenylalanine: R group, shortened form, and what is the fully shortened form?
CH₂-benzene
Phe
F
Tyrosine: R group, shortened form, and what is the fully shortened form?
CH₂-benzene-OH
Tyr
Y
Tryptophan: R group, shortened form, and what is the fully shortened form?
CH₂ - C = CH - NH
⠀⠀⠀⠀\CH-CH/
lC₆H₆l
Trp
W
Histidine: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH₂-CH-NH=CH
⠀⠀⠀\CH-NH/
His
H
Arginine: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH₂-CH₂-CH₂-NH-C=NH₂⁺
⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀\NH₂
Arg
R
Lysine: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH₂-CH₂-CH₂-CH₂-NH₃⁺
Lys
K
Threonine: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH-CH₃
⠀⠀⠀\OH
Thr
T
Serine: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH₂-OH
Ser
S
Methionine: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH₂-CH₂-S-CH₃
Met
M
Cysteine: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH₂-SH
Cys
C
Asparagine: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH₂-C=O
⠀⠀⠀⠀\NH₂
Asn
N
Glutamine: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH₂-CH₂-C=O
⠀⠀⠀⠀⠀⠀⠀\NH₂
Gln
Q
Aspartic acid: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH₂-C=O
⠀⠀⠀⠀\O⁻
Asp
D
Glutamic acid: R group, an interesting fact, shortened form, and what is the fully shortened form?
CH₂-CH₂-C=O
⠀⠀⠀⠀⠀⠀⠀\O⁻
Glu
E
Aliphatic amino acids
Glycine, Alanine, Valine, Isoleucine, Leucine, Proline
Aromatic amino acids
Histidine, Phenylalanine, Tyrosine, and Tryptophan
Acidic amino acids
Aspartic acid, Glutamic acid
Basic amino acids
Lysine, Arginine, Histidine
Sulfuric amino acids
Cysteine, Methionine
Hydroxylic amino acids
Threonine, Serine, Tyrosine
Amidic amino acids
Glutamine, Asapargine