Lecture 14 - Metabolism introduction and catabolism

Question 1

Single step pathways

Answer 1

Uncontrolled oxidation occurs, releasing one large burst of energy

Question 2

Multistep pathways

Answer 2

Occurs in organelles using one enzyme for each reaction, releasing smaller amounts of energy at higher frequencies

Question 3

Metabolic pathways

Answer 3

Highly regulated

Question 4

Heat generation

Answer 4

Strong way of producing heat is by simultaneously undergoing glycolysis and gluconeogenesis

Glycolysis:
ATP + fructose-6-P ⇌ fructose-1,6-bisP + ADP

Gluconeogenesis:
Fructose-1,6-bisP + H₂O ⇌ fructose-6-P + ATP

Question 5

Feed-forward reaction

Answer 5

A metabolite early in the pathway activates an enzyme later in the pathway, reaching the final metabolite quicker

Question 6

Allosteric

Answer 6

Binds to another point on the enzyme and causes an effect (either activatory or inhibitory)

Question 7

Protein phosphorylation

Answer 7

Protein phosphorylation - protein kinase
Protein phosphate removal - protein phosphatase