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Bio 111 > Lecture 4 > Flashcards

Lecture 4 Flashcards

Cell Cycle Control, Cell Cycle Checkpoints

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Biology 101 flashcards
1
Q

Cyclins

A

regulatory proteins that accumulate & degrade in a cell-cycle specific pattern

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2
Q

What do cyclins do?

A

control the cell cycle, regulate kinases, regulate CDKs

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3
Q

What would happen if cell didn’t have cyclins?

A

It would stop

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4
Q

Kinases

A

protein enzymes that phosphorylate other molecules

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5
Q

Phosphorylate

A

add phosphate group to

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6
Q

Phosphatases

A

enzymes that dephosphorylate other molecules

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7
Q

Dephosphorylate

A

remove phosphate group from

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8
Q

What does CDK stand for?

A

Cyclin Dependent Kinases

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9
Q

CDKs

A

kinases that are inactive unless attached to cyclin protein

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10
Q

What happens when CDKs are activated?

A

they can phosphorylate their target proteins

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11
Q

Cell Cycle Checkpoints (CCCPs)

A

points where progression of cell cycle can be stopped

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12
Q

Purpose of CCCPs

A

prevent cells from proceeding through cell cycle when not appropriate

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13
Q

overall result of activated CDKs

A

charge within cell that advances cell cycle

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14
Q

3 Main Cell Cycle Checkpoints

A

G1/S, G2/M, Spindle

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15
Q

G1/S Checkpoint

A

commitment to divide at all

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16
Q

G2/M Checkpoint

A

commitment to proceed into mitosis/meiosis

17
Q

The Spindle Checkpoint

A

commitment to proceed into anaphase (segregate replicated DNA)

18
Q

What regulates the G1/S Checkpoint?

A

cyclins/CDKs

19
Q

What regulates the G2/M Checkpoint?

A

cyclins/CDKs

20
Q

What regulates the Spindle Checkpoint?

A

APC (Anaphase Promoting Complex)

Bio 111 (4 decks)

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