Lecture 4

Question 1

Rh refers to

Answer 1

specific red blood cells antigens and a complex blood group system

Question 2

How did Rh factor get it’s name

Answer 2

anti-body made by guinea pigs and rabbits when they were transfused with rhesus monkey RBC’s

Question 3

erythroblastosis fetalis

Answer 3

hemolytic disease of the newborn
Rh is a primary

Question 4

Fisher-Race

Answer 4

the antigen of the system were produce by three closely linked sets of alleles

Question 5

What are the allele sets of Fisher-Race

Answer 5

D, d, C, c, E, e

Question 6

In Fisher-Race what does “d” mean?

Answer 6

represents the absence of D

Question 7

What is the order for Fisher-Race?

Answer 7

D then C then E

Question 8

An Rh positive person exhibiting a deletion phenotype is written

Answer 8

–De or –DE, CD-, or cD, or –D-
Meaning not showing C/c or E/e

Question 9

A person expressing no Rh antigens on RBCs

Answer 9

Rhnull
written phenotypically as __/__

Question 10

Rhmod phenotype

Answer 10

Weakened expression of all Rh antigens

Question 11

Weiner: The Rh-Hr Terminology

Answer 11

the Rh gene produces at least three factors within an agglutinogen

Question 12

Agglutinogen

Answer 12

A substance that stimulates the production of an agglutinin

Question 13

Rosenfield

Answer 13

As the Rh blood groups system expanded it became difficult to assign names to new antigens
no genetic basis
suited for electronic data processing

Question 14

ISTB Numeric Terminology

Answer 14

six-digit number for each blood group specificity

Question 15

ISTB Numeric Terminology: Numbers

Answer 15

First 3 numbers represent the system
remaining 3 the antigen specificity

Question 16

two closely linked genes control the expression of Rh

Answer 16

RHD and RHCE
Located on chromosome #1

Question 17

RHD

Answer 17

codes for the presents or absence of the D polypeptide

Question 18

RHCE

Answer 18

codes for the presents orabsence for either RHCe, RHcE, RHce, or RHCE polypeptides

Question 19

RHAG

Answer 19

reside on chromosome # 6
forms complexes with the Rh polypeptides
coexpressor and must be present for the successful expression of the Rh antigens

Question 20

Genetic Weak D

Answer 20

Most commonly seen in blacks & very rare in whites
At the molecular level these quantitative differences in D expression are attributed to mutations of the Rh polypeptide

Question 21

C Trans

Answer 21

In individuals showing the gene interaction weak D, the allele carrying D is trans
in the opposite haplotype
Position effect

Question 22

C Trans: Other facts

Answer 22

steric arrangement of C in relation to D interferes with expression of D

Question 23

Partial D (D Mosaic)

Answer 23

Occurs when one or more of the D epitopes within the entire D protein is either missing and/or is altered

Question 24

Cells with a partial D usually type…

Answer 24

weaker than expected or may not react at all