Lecture 4 Flashcards
Where is lipoprotein lipase absent
brain and liver
Where is LPL attached to?
sulfate proteoglycan on surface of capillary endotheliium
which chylomicrons bind to as they pass
When chylomicrons bind to LPL as they pass through sulfate proteoglycan on surface of capillary endothelium; the TG are hydrolyzed to what?
what happens to them?
FFA and 2-Monoacylglycerols
They diffuse freely into tissues
Each tissue has its own isoenzyme of LPL
Does LPL activity increase or decrease in fasting state?
Decrease
Except in skeletal muscle and myocardium; they stay moderate in either state
Following a fatty meal TG’s enter where?
adipocytes
In the transition period between meal and fasting TG’s are sent where?
Skeletal muscle and myocardium
What solubilizes LPL when injectedin skin?
Heparin, increasing LPL activity
The assessment is based on serumlipase activity level pre/and post heparin injection
When TAG is hydrolyzed and a glycerol is released, it does what?
Provides substrate for gluconeogenesis
What’s the primary regulation of gluconeogenesis
Availibility of substrates (glycerol)
Circulating level of glucagon
What’s the secondary regulation of gluconeogenesis?
Adaptive changes in the rate of enzyme synthesis, degradation or both
How many amino acids in glucagon?
Is it alpha or beta?
It’s made as a large precursor and converted to glucagon how?
29
alpha
By series of proteolytic enzyme cleavage
What’s the role of glucagon?
maintain normal blood glucose level
Epinephrine and Norepinephrine is made where?
Adrenal medulla which is mediated by autonomic nervous system
and triggered by Hypothalamic glucoreceptors
Cortisol is made where?
Adrenal Zona Fasciculata and Reticularis
What triggers growth hormone
adrenal corti co tropic hormone & anterior pituitary glands stored in somatotroph cells
