Lecture 3a

Question 1

What are the hemostatic system players?

Answer 1

Blood proteins (procoagulant and anticoagulant factors)
Platelet
Vessel wall

Question 2

Where are the platelets concentrated in?

Answer 2

1/3 released from bone marrow or transfused are pooled in spleen

Question 3

What are some of the platelet granules?

Answer 3

Denise granules
Alpha granules

Question 4

What does thromboxane do?

Answer 4

Activate other platelets and increasing clotting

Question 5

Where are von williebrand factors made and stored?

Answer 5

Endothelial cells and platelets

Question 6

What is the principle of secondary hemostasis?

Answer 6

Clotting factors activate each other (cascade effects, circulates inactivated otherwise)
There are checks and balances

Question 7

What does thrombin do?

Answer 7

It gives positive feedback to create more and more thrombin

Question 8

What are the three essential steps for blood coagulation?

Answer 8

Prothrombin activator formed
Prothrombin to thrombin
Thrombin converts fibrinogen to fibrin

Question 9

What kind of disease affect blood clotting?

Answer 9

Liver disease

Question 10

What clotting factors for vitamin K?

Answer 10

Factors 2,7,9,10, protein C, protein S

Question 11

How much stronger is the intrinsic pathway than the extrinsic pathway?

Answer 11

100x

Question 12

What is the most abundant coagulation protein?

Answer 12

Fibrinogen

Question 13

What are the anticoagulant plasma proteins?

Answer 13

Protein C + S
Anti-thrombin (III)
Tissue factory pathway inhibitor
Fibrinolysis

Question 14

What does Anti-thrombin do?

Answer 14

Inactivates thrombin, 9a, 10a, 11a, 12a
Inhibition accelerate 1000x with heparin

Question 15

What is fibrinoylysis?

Answer 15

The breakdown of fibrin

Question 16

What do we order when we think someone has a blood clot?

Answer 16

D-dimer (if positive likely to have a clot)

Question 17

What is the function of tPA?

Answer 17

Converts of plasminogen to plasmin