Lecture 34 Flashcards
Where do IgM and IgD producing cells come from
Primary focus
Which immunoglobulins to memory B cells express
Mainly–>IgG (some IgA and IgE) and further undergoing somatic hypermutation
Some–> IgM
What does Memory B cells express higher levels of than naive B cells
Higher levels of
1) MHC class II
2) CD40
3) Receptors for survival and proliferation
Where do Memory B cells reside
Circulate in blood
Reside in spleen and lymph nodes
Types of Memory T cells
Central memory T cells (Tcm) and Effector memory T cells (Tem)
Where do Central memory T cells (Tcm) reside/travel
Between secondary lymphoid tissues
Effect on Central memory T cell after second antigen exposure
Rapidly reactivate
Which memory T cell can differentiate into several subtypes
Central memory T cell (Tcm), depending on cytokine environment
ex. (Th1, Th1…)
Where do Effector memory T cells (Tem) travel
To/Between Tertiary tissues
Which Memory T cell contributes better to first-line defense
Effector memory T cells (Tem) as they can interact with local APC
Effect on Effector Memory T cell (Tem) after second antigen exposure
Shift right back into effector functions
Do Memory T cell require strong co-stimulatory signal or cytokines
NO, already have large expression of CD28
What differentiated Tcm and Tem
Location and commitment to effector function
Which T cells are memory T cells closer to
Closer to effector T cells than naive T cells
Memory T cell vs effector T cell
Memory T cell
1) Requires less for activation
2) Express unique set of receptors (different surface adhesion molecules and costimulatory receptors)
3) Less sensitive to restimulation, but still require contact with p:MHC
Become effector upon reactivation
