Lecture #31: Renal Histolgy II Flashcards

1
Q

What type of epithelium is found in the thin segment of the loop of Henle?

A

Simple Squamous Epithelium

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2
Q

Do the cells of the thick ascending limb have a brush border?

A

NO

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3
Q

Which limb, ascending or descending, of the loop of Henle is impermeable to water?

A

The ascending lib is impermeable to water.

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4
Q

What is the descending thin limb of the loop of Henle permeable to?

A

Descending thin limb is permeable to water and sodium and chloride ions.

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5
Q

True or False:

The ascending thin limb is impermeable to water and actively pumps chloride ion out of the tubule, allowing sodium ions to follow.

A

True

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6
Q

What is the major function of the loop of Henle?

A

To establish the counter-current exchange system which creates the osmotic conditions necessary to pull water out of the distal convoluted tubule and collecting duct in the presence of ADH.

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7
Q

What kind of epithelium lines the distal convoluted tubule?

A

Lined with simple cuboidal epithelium with smaller cells than those of the proximal convoluted tubule.

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8
Q

Compare the lumen of the distal convoluted tubule and the proximal convoluted tubule.

A

The lumen of the distal convoluted tubule is larger than that of the proximal convoluted tubule and there is no brush border.

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9
Q

Is the cytoplasm of the distal convoluted tubule less eosinophilic than that of the proximal convoluted tubule?

A

Yes

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10
Q

The distal convoluted tubule is impermeable to water, except in the presence of what hormone?

A

ADH

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11
Q

Where is antidiuretic hormone derived from?

A

Derived from the posterior pituitary.

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12
Q

What does ADH function to do?

A

Functions to reduce water loss.

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13
Q

What is antidiuretic hormone also known as?

A

vasopressin

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14
Q

Look at figure 14-14

A

It will help show you how to determine between the PCT and DCT.

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15
Q

What do principal cells do?

A

Reabsorb sodium ions and water and secrete potassium via ATPase pump.

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16
Q

What do intercalated cells secrete?

A

Secrete either hydrogen or bicarbonate ion

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17
Q

True or False:

The collecting duct has a different embryological origin than that of the nephron.

A

True

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18
Q

What kind of epithelium is found in the thick segments of the loop of Henle?

A

Simple Low Cuboidal Epithelium

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19
Q

What kind of epithelium does the wall of the collecting duct consist of?

A

Simple Cuboidal Epithelium

20
Q

What two types of specialized cell types are associated with the collecting duct?

A

> principal cells

> intercalated cells

21
Q

What are the layers that make up the renal pelvis, ureter, and urinary bladder, starting at the mucosa and going out to the adventitia?

A

Mucosa

Submucosa (not clearly demarcated)

Muscularis

Adventitia (FECT external to muscularis; serosa over superior surface of bladder).

22
Q

What does the mucosa of the renal pelvis, ureter, and urinary bladder consists of?

A
> transitional epithelium (urothelium)
> basement membrane
> lamina propria of FECT
> some loose lymphoid tissue
> a few smooth muscle cells
23
Q

Does the lower or upper third of the ureter have a third external longitudinal muscle coat?

A

Lower Third

24
Q

Other than in the lower third of the ureter, what does the muscularis layers consist of that make up the rest of the ureter?

A

inner longitudinal and outer circular smooth muscle coat in ureter.

25
Q

What do the layers of smooth muscle in the urinary bladder form?

A

Detrusor Muscle

26
Q

What kind of epithelium lines the mucosa of the prostatic urethra?

A

Transitional Epithelium

27
Q

True or False:

The prostatic urethra is lightly vascularized with veins that have abundant elastic tissue in them.

A

False - prostatic urethra is highly vascularized with veins that have abundant elastic tissue in them.

28
Q

What type of epithelium lines the membranous urethra?

A

Tall pseudostratified columnar cells (but variable)

29
Q

True or False:

The membranous urethra extends through the urogenital diaphragm and receives striated muscle cells forming the external sphincter of the bladder.

A

True

30
Q

What type of epithelium lines the cavernous urethra?

A

Lined with pseudostratified epithelium with patches of stratified squamous epithelium.

31
Q

What are the two types of glands that are found in the male urethra?

A

> Lucanae of Morgagni are invaginations of mucous membrane containing single or groups of intraepithelial mucous cells.

> Glands of Littre are branched tubulara glands opening into the lacunae of Morgagni

32
Q

What type of epithelium is the mucosa of the female urethra primarily lined with?

A

Stratified or pseudostratified columnar epithelium with intraepithelial nests of mucous glands.

33
Q

True or False:

The lamina propria of the female urethra is highly vascularized with veins with an abundance of elastic tissue.

A

True

34
Q

True or False:

The submucosa and adventitia of the female urethra is not discernible on micrograph.

A

True

35
Q

Which layers of the female urethra muscularis layer are longitudinal and which one is circular?

A

Inner longitudinal and an outer circular layer of smooth muscle cells, but they’re not well defined.

36
Q

List the functions of angiotensin II.

A

> Stimulates secretion of aldosterone from adrenal cortex

> Aldosterone acts on the principal cells of the collecting ducts and the thick ascending limbs of Henle

> Increases reabsorption of sodium ion and water which increases blood pressure

> Stimulates release of ADH

37
Q

Where is ACE (angiotensin-converting factor from?

A

Pulmonary and Renal Endothelium

38
Q

Where is angiotensinogen from, and where is it found?

A

Circulating blood protein from the liver.

39
Q

Where is angiotensin I primarily produced?

A

Lungs

40
Q

What converts angiotensionogen to angiotensin I?

A

Renin

41
Q

What converts angiotensin I to angiotensin II?

A

ACE

42
Q

What factors stimulate the tubuloglomerular feedback system to trigger the renin-angiotensin-aldosterone system?

A

1) a depletion of the extracellular fluid compartment
2) a decrease in renal blood pressure (hypotension)
3) a decrease in [Na] (sodium) at the macula densa

43
Q

What does angiotensin II stimulate?

A

1) aldosterone secretion by adrenal cortex
2) arteriolar vasoconstriction (increases bp)
3) ADH secretion and thirst
4) reabsorption of NaCl by the proximal convoluted tubule

44
Q

What does aldosterone do?

A

Secreted by the adrenal cortex -> it reduces the excretion of NaCl by stimulating its reabsorption by the thick ascending limb of the loop of Henle, the distal convoluted tubule, and the collecting tubule.

45
Q

What does the afferent arteriole behave as?

A

Pressure Receptor

**when blood pressure is reduced, the secretion of renin is stimulated.