Lecture 3: What causes ageing Flashcards
What does Orgels error catastrophe theory suggest?
The mistranslation of mRNA leads to a faulty protein which leads to more mistranslation
What’s the rate of living theory?
All animals use same amount of calories per body mass over the lifespan
When does the rate of living theory work well?
Within phyla
Give two exceptions to the rate of living theory?
Little brown bat
Storm petrel
What are the 4 main types of damaged biomolecules in the free radical theory?
DNA
Lipids
Proteins
Sugars
What DNA oxidation is commonly observed?
8-oxoG
What are 2 examples of lipid peroxidation?
MDA and HNE
How was Orgels theory disproven on error catastrophe?
No increase in altered, abnormal protein with age
No increase error rate of DNA polymerase from mice aged 40 months vs. 6 months
Amino acid analogues producing non-functional proteins were fed to Drosophila; no lifespan shortening
Who came up with the rate of living theory?
Pearl
What evidence backed the rate of living theory?
In insects, cold temperatures slowed metabolic rate which increased lifespan
According to the rate of living theory, a high metabolic rate leads to what?
Shorter lifespan
What correlation was found to support the free living theory?
Basal metabolic rate is inversely proportionate to lifespan.
This was statistically significant
Who came up with the free radical theory of ageing?
Harman
What does the free radical theory suggest?
Irradiation induces free radical formation and shortens lifespan
What is the theory behind the free radical theory?
Faster BMR
More free radicals
More damage
Shorter lifespan
