Lecture 3 + Readings Flashcards

1
Q

Symptoms/diagnostic criteria of MDD

A

At least 1 of core symptoms
•Depressed mood
•Loss of interest in activities or people
AND TOTAL of at least 5 (including at least one of the core):
•Marked insomnia or hypersomnia
•Low energy
•Appetite disturbance
•Psychomotor retardation or agitation
•Feeling of worthlessness or guilt
•Poor concentration or indecision
•Thoughts of death and/or suicide
Symptoms last at least 2 weeks (avg. is 6 months)
Symptoms must cause clinically significant distress/impairment
Symptoms interfere with normal functioning

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2
Q

What is the lifetime prevalence of MDD?

A

10-15% (some studies 20%)

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3
Q

Depression increases suicide risk by how much?

A

4xs

responsible for 70% of suicides

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4
Q

What is secondary depression?

A

Secondary depression is when another illness is the cause of the depression
ex: someone diagnosed with cancer then becomes depressed

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5
Q

Explain relationship between overall health and depression

A

Depression worsens overall health of chronically ill patients by about 10%

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6
Q

Recurrence

A

85% of people have a recurrence

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7
Q

Predictors of recurrence

A

being female, more prior episodes*, longer episodes, never marrying

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8
Q

Prior episdoes

A

The risk for another recurrence goes up 16% after each episode.

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9
Q

Teens with depression

A

increases rates of suicide - 5xs more likely than non-depressed

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10
Q

Persistent or Chronic Depression

A
Longer duration 
More severe symptoms 
More comorbidity 
Poorer social support
Poorer response to treatment 
Family history of affective disorders
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11
Q

What is the link between poor social support and chronic depression?

A
  • Persistent depression can decrease someone’s motivation to get help = poor social support, Or even a feedback system – they might not be so nice to other people and therefore they don’t want to deal with them…
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12
Q

Anger in depression

A

isn’t an official symptom - but 40% of MDD have this.

but unrecognized

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13
Q

Disruptive Mood Regulation disorder

A

characterized by anger/irritable outbursts quite often

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14
Q

When are you considered in recovered from MDD?

A

2 months symptom free

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15
Q

What is remission in MDD?

A

still some symptoms, but don’t meet criteria for diagnosis

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16
Q

What are the SCID and K-SADS

A

Interview measures for depression
SCID for adults
K-SADS for kids

17
Q

What are
Beck Depression Inventory
Hamilton Depression Rating Scale
Montgomery-Asberg rating scale

A

Self-report measures of depression

18
Q

Brain areas involved in depression

A
Less activation: 
- Prefrontal Cortex (PFC), Cingulate 
More activation: 
- Amygdala
- Orbital cortex (OC)
19
Q

Family studies and depression

A

1st degree relative 2-5x more likely to develop unipolar depression

20
Q

Twin studies and depression

A

Concordance rates for unipolar depression:

  • 40-59% for MZ twins
  • 20-30% for DZ twins

Bipolar disorder 65% MZ and 14% DZ

21
Q

Adoption studies and depression

A

Adoption studies:

- rates of bipolar disorder in biological relatives = 32% vs. 12% of adoptive relatives

22
Q

Serotonin

A

Involved in regulation of emotion
Low serotonin linked to depression; but not the cause*
Serotonin pathway to PFC important in mood regulation and mechanisms of antidepressants

23
Q

Norepinephrine

A

Mostly related to anxiety

Plays a role in depression

24
Q

Brain-derive Neurotrophic factor (BDNF)

A

Important in neuroplasticity
Episodic and emotion-related memory, fear
Stress = decreased hippocampal BDNF

25
Q

CBT on depression

A

CBT reverses altered activation patterns to emotional stimuli = cognitive therapy can affect the activity of the brain regions involved in how emotions are processed

*Based on studies using MRI and fMRI

26
Q

Integration of CBT and biology

A

Cognitive related therapies lead to brain alterations

Biological vulnerability and cognitive vulnerability might be related