Lecture 17 - OCD Flashcards

1
Q

OCD

A
  • Prevalence: 2-3%
  • M/F ratio almost equal. Males often earlier onset and more comorbidity
  • Low spontaneous remission rates
  • Most common comorbidity: MDD (67%), simple phobia (22%); social phobia (18%); eating disorder (17%).
  • Egodystonic (thoughts/behaviours in conflict with needs/goals of ego or ideal self image)
  • Average age of onset=20 y, 25% of the cases in adolescence (age 14)
  • Onset is often gradual
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2
Q

Obsession; Compulsion

A

Obsession: Intrusive, unwanted thoughts or images

*Rare: Occurrence of obsessions without compulsions

Compulsion: Ritualized behaviors or mental acts,
generally performed to reduce anxiety related to the obsession
- Sense of pressure to act
- Attribution of the pressure to internal causes
- Source of distress

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3
Q

Classes of obsessions

A

1) Contamination: ex: my colleague used my pen, I am going to get his cold
2) Responsibility for Harm: ex: what if I put poison in my kid’s lunch?
3) Symmetry/order: ex: odd numbers are harmful/incorrect
4) Unacceptable Thoughts: ex: impulse to stab husband

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4
Q

Neutralization

A
  • Strategies to control, remove, or prevent obsessions
  • Not compulsions – not stereotyped or repeated; not prevent an outcome but the obsession
  • Overanalyzing and rational selftalk, deliberately
  • Seeking reassurance
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5
Q

Compulsions

A
  • Most visible and functionally disabling features
  • Motivated and intentional
  • Performed to reduce stress
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6
Q

Categories of Compulsions

A
  • Decontamination
  • Checking
  • Repeating routine activities
  • Ordering/arranging
  • Mental rituals
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7
Q

Differential Diagnoses (comorbidities)

A

specific phobia, obsessive compulsive personality disorder, GAD

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8
Q

Behavioural models of OCD - Mowrer two factors theory

A
  • CC: intrusive thoughts associated with anxiety

- OC: compulsions are negatively reinforced because they reduce the anxiety (safety/neutralizing behaviors)

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9
Q

Behavioural therapy

A

Exposure and response prevention (exposure to fear evoking stimuli and assistance with resisting urges
to avoid or escape using compulsive behaviors)
- Effective but difficult

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10
Q

Salkovski’s cognitive behavioural theory of OCD

A
  • Unwanted intrusive thoughts are normal: 90% of population experience them
  • Ego-dystonic
  • Individuals with OCD appraise these unwanted as
    highly significant and/or threatening.
  • These negative appraisals increase the frequency
    and intensity of intrusive thoughts.
  • Engage in series of overt and covert behaviors to
    avoid having intrusive thoughts

Normal thoughts, images, and impulses are indications of:
- Harm to themselves or other is a serious risk
- They may be responsible for this harm or its prevention
leads to“inflated” responsibility
Leads to:
- Increased discomfort.
- Increased attention to the intrusions and external triggers of the intrusions.
- Increased accessibility to the original intrusion and other related ideas.
- Behaviors such as compulsions, and thought suppression to escape from it

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11
Q

Rachman’s cognitive theory

A
  • Obsessions are caused by catastrophic misinterpretations of the significance of one’s thoughts
  • Not limited to responsibility appraisals
  • Interpret the intrusive thought has personal significance:
    • Imply that the person is bad, mad, or dangerous
    • Catastrophic interpretation elicits anxiety
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12
Q

Thought - Action infusion

A
  • Belief that having an intrusive thought increases the likelihood that a specific adverse event will occur.
  • Belief that having an intrusive thought is almost the moral equivalent of carrying out that particular act.
  • Increase the likelihood of catastrophic interpretation of unwanted thoughts.
  • OCD patients report greater TAF than controls
    • But TAF seen across anxiety disorders
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13
Q

Purdon and Clack’s Thought control

A
  • Faulty beliefs about the importance of controlling one’s thoughts
  • Negative misinterpretations of the consequences of failure to control unwanted thoughts.
  • Consequences:
    • Heightened vigilance to the occurrence of intrusive thoughts
    • Active resistance and attempt to suppress intrusive thoughts
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14
Q

Thought suppression

A
  • Thought suppression: usually unsuccessful.
  • Paradoxical thought rebound
  • Increase psychological distress
  • Results in escalating attempt to regain control
  • This lead to increased catastrophic appraisals
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15
Q

Cognitive - Behavioural treatment

A
  • Exposure & Response Prevention
    • Effective, but difficult treatment.
  • Behavioral experiments: a tool to test the patient (maladaptive) beliefs
  • Response prevention can target the beliefs of increased responsibility
  • Cognitive therapy: evaluate the appraisal of unwanted intrusive thoughts
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16
Q

Biological Factors

A

Genetic factors:

  • Twin studies: 27-47% heritability (adults)
  • Family studies: OCD is familial
  • Candidate gene studies: potential genes in serotonergic and dopaminergic pathways
17
Q

Bran mechanisms

A

Anterior cingulate cortex (ACC)
Orbital Frontal Cortex (OFC)
Basal ganglia (esp. Head of Caudate nucleus)
All increased activity + reduced size of the caudate

18
Q

Treatment

A

CBT regarded as an effective treatment for OCD, with exposure and response prevention (ERP)
Pharmacotherapy: SSRIs
Last-line treatment (and extremely rare and only in very severe cases): neurosurgery