Lecture 3 - Hypothyroid Flashcards
wolf-chaikoff:
____ doses of iodine cause a ____ in hormone production
high;
decrease
jod-basedow effects:
____ doses of iodine causes a ____ in hormone production
high, increase;
seen in hyperthyroid patients
hypothyroidism:
_____myxedema, causing a large ____ and deepening of the _____;
____, ____ hair
facial/periorbital;
tongue, voice;
coarse, brittle
primary hypothyroidism:
____ free T4, _____ TSH;
secondary hypothyroidism:
____ free T4, ____ TSH
low, high;
low, normal or low
drug of choice for hypothyroidism:
side effects?
levothyroxine;
hyperthyroid symptoms ie tachycardia, arrythmias
hashimoto’s:
HLA ____ associated;
anti ______ and anti _____ antibodies;
increased risk of ____ cancer
DR5;
thyroid peroxidase, thyroglobulin;
marginal zone
riedel thyroiditis:
seen in ____ women;
presence of _____;
goiter is described as ____ and _____
younger (vs anaplastic carcinoma);
fibrosis (extending to other structures);
painless, rock hard
pregnancy causes an increase in ____ synthesis due to ____ stimulation. T4 and T3 levels ____ in the first trimester
Thyroid-binding globulin;
estrogen;
increase
in patients with hypothyroidism, what is seen when the check DTRs?
delayed relaxation phase
and delayed DTRs
in pregnancy, ____ has intrinsic thyrotropic activity;
in the second and third trimesters, thyroid levels ____
HCG;
decrease
myxedema coma:
low _____ leads to build up of ____ within cell leading to cellular _____
metabolism;
metabolites;
edema
myxedema coma:
____ edema; _____ cardiac output and _____ perfusion, organ failure
non-pitting (widespread); decreased, decreased
thyroid cancer nodules are usually ____ on scan. thyroid cysts are (likely or unlikely) to be cancer
cold;
unlikely
thyroid cancer is typically diagnosed with _____
fine needle aspirate
iron and calcium _____ thyroid hormone absorption
decrease
also anti-acids, PPIs, bile acid resins
