Lecture 3: Formation of Urine 1

Question 1

what are the stages of urine formation

Answer 1

1) glomerular filtration of blood
2) proximal tubule reabsorption of filtrate and secretion into tubule
3) loop of henle concentration of urine
4) distal tubule modification of urine
5) collecting duct final modification of urine

Question 2

how do the afferent and efferent arterioles differ

Answer 2

afferent is wider than efferent, so pressure leaving is higher than entering

Question 3

what is the healthy glomerular filtration rate

Answer 3

125 mL/min

Question 4

what is the value for net filtration pressure

Answer 4

10 mm Hg

Question 5

in which range is autoregulation of renal blood flow maintained

Answer 5

90 - 200 mmHg

Question 6

where is AQP 1 found

Answer 6

proximal tubule

Question 7

where is AQP 2 found

Answer 7

collecting duct on apical surface

Question 8

where are AQP 3 and 4 found

Answer 8

basolateral surface of tubular cells involved in water reabsorption

Question 9

which glucose transporters are involved in the proximal convoluted tubule

Answer 9

• SGLT2 for cotransport of sodium and glucose into the cell

- GLUT2 for reabsorption of 90% of glucose

Question 10

which glucose transporters are involved in the straight proximal convoluted tubule

Answer 10

• SGLT1 for cotransport of sodium and glucose into the cell

- GLUT1 for reabsorption of 10% of glucose

Question 11

which types of drugs are SGLT2 inhibitors

Answer 11

flozins