Lecture 3

Question 1

Skeletal Muscle structures

Answer 1

1- Sarcolemma
2- T-tubules
3- Sarcoplasmic reticulum
4- Terminal Cisternae
5- Mitochondria
6- Myofibrils
7- Sarcomeres

Question 2

Myofilaments

Answer 2

1- Thick filament

2- Thin filaments

Question 3

Thick filaments

Answer 3

Myosin

Question 4

Thin Filaments

Answer 4

1- Actin
2- Tropomyosin
3- Troponin

Question 5

Review slides 7-10

Answer 5

review slides son!

Question 6

Intercalated Discs

Answer 6

The plasma membranes of adjacent cardiac muscle cells interlock at dark-staining junctions

Question 7

type of Intercalated Discs

Answer 7

1- Desmosomes

2- Gap Junctions

Question 8

Desmosomes

Answer 8

Prevent adjacent cardiac cells from separating during contraction

Question 9

Gap Junction

Answer 9

Allow ions to pass freely from cell to cell, directly transmitting the depolarizing current across the entire heart

Question 10

Functional Syncutium

Answer 10

Cardiac fibers are electrically coupled by the gap junctions, the entire myocardium behaves as a single coordinated unit

Question 11

Three proteins that cardiac troponin consists of

Answer 11

1- Cardiac Troponin C (cTnC)
2- Cardiac Troponin I (cTnI)
3- Cardiac Troponin T (cTnT)

Question 12

Cardiac Troponin C

Answer 12

Calcium Binding

Question 13

Cardiac Troponin I

Answer 13

Inhibitory

Question 14

Cardiac Troponin T

Answer 14

Tropomyosin binding

Question 15

Skeletal and cardiac troponinT (as well as I) differ

Answer 15

in amino acid sequence

Question 16

Angina and myocardial infraction

Answer 16

-due to myocardial ischemia
-Chest Pain
-

Question 17

Myocardial ischemia results of

Answer 17

atherosclerosis

Question 18

Pain associated in anginal

Answer 18

1- Exertion
2- Emotion
3- eating
4- cold
short lived and relieved by NTG (Nitroglycerine)

Question 19

Myocardial Infraction pain

Answer 19

• occurs spontaneously
• more long-lasting
• not relieved by NTG (nitroglycerine)

Question 20

Angina characteristics

Answer 20

1- no cell death to myocardium

due to resupply of blood

Question 21

Myocardial Infraction characteristic

Answer 21

1- Cell death

2- my result in death if enough cells die.

Question 22

Prefered markers for detecting myocardoial cell injury

Answer 22

Cardia Troponin I (cTnI) or T (cTnT)

• both rise 2-6 hours after injury
• both peak in 12-24 hours
• cTnl can stay elevated for 5-8 days
• cTnT for 5-14 days