Lecture 25

Question 1

these originate from posterolateral mesoderm during gastrulation and organize into blood islands in cold sac around day 18

Answer 1

hemangioblasts

Question 2

the hematopoietic lineage of henamgioblasts are influenced by

Answer 2

Runx-1

Question 3

the endothelial lineage of hemangioblasts are influenced by

Answer 3

Hoxa3

Question 4

this organ is the major producer of blood cells from week 6 to 6 months, it then switches to bone marrow

Answer 4

liver

Question 5

the recruitment of angioblasts is and involves VEGFR-2 and VEGF-A

Answer 5

vasculogenesis

Question 6

this is part of the vascular system formation and involves angiopoietin-1 and Tie-2 and the notch signaling pathway

Answer 6

sprouting

Question 7

theses cells release platelet-derived growth factor and stimulates immigration of mesenchymal cells

Answer 7

endothelial cells

Question 8

the arterial pathway involves what 2 signaling factors

Answer 8

Shh and notch

Question 9

this membrane bound ligand is expressed in developing arteries

Answer 9

Ephrin-B2

Question 10

this membrane bound ligand is expressed in developing veins

Answer 10

Eph-B4

Question 11

this pathway is initiated via transcription factor COUP-TFII and inhibits the arterial pathway by inhibiting notch

Answer 11

venous pathway

Question 12

this branches off veins and requires Sox-18 followed by Prox-1

Answer 12

lymphatics

Question 13

there are 6 pairs of these and they connect ventral aorta to paired dorsal aorta

Answer 13

aortic arches

Question 14

what are the three groups of aortic branches?

Answer 14

dorsal, ventral and lateral intersegmental

Question 15

what are the three cardinal vein pairs?

Answer 15

anterior, posterior, common

Question 16

all blood from the head is shunted to the right and drained into the right cardinal veins into the ?

Answer 16

superior vena cava

Question 17

the vitelline vein, subcardinals, supra cardinals, and iliac make up what?

Answer 17

inferior vena cava