Lecture 23 Flashcards
What are the mucosae/
These are layers of epithelial cells that line the body passage such as a gut, respiratory tract or urogenital tract
Where do the mucosae get their name from?
Their capacity to produce mucus which is a viscous solution of polysaccharides in water that covers the apical surface membrane of an epithelial cell it also contains sIgA, sIgM and antimicrobial molecules
What are the different sites in mucosal immunity terminology?
Inductive sites which are areas in the mucosae in which antigen is encountered and a primary adaptive response is initiated
Effector sites which are areas in the mucosae where effector lymphocytes are dispatched after mucosal T and B cells are activated in a given inductive site
What are examples of inductive sites?
The payers patches, appendix, tonsils, bronchial epithelium, diffuse intestinal follicles
What are examples of effector sites?
Lacrimal and nasal glands, salivary gland, tracheal and bronchial gland, mammary gland, intestinal mucosa, urogenital tract
What is the basic structure of GALT components?
Gut epithelium consisting of crypts and villi
Lamina propia in which macrophages, neutrophils, immature dendritic cells, NKTs memory alpha/beta T cells and memory B cells
How does antigen sampling occur in GALT?
M cells are specialised epithelial cells which take up antigen from the lumen and pass it on to intestinal follicles through its intraepithelial pocket
These follicles contain dendritic cells which take up the antigen and regulate B and T cell responses with immature dendritic cells tolerizing naïve T cells
What is the function and basic structure of Nasopharynx and bronchi associated lymphoid components?
These function to provide immune protection from dubious substances and pathogens inhaled in the air
NALT has a basic structure containing nasal submucosal glands, tonsils, upper airway epithelial layers, nose hairs and cilia
BALT has a basic structure containing bronchial submucosal glands, tracheal, bronchi and lung epithelial layers and cilia
What is the basic structure of SALT?
There is the epidermis consisting of the keratin layer and lower epidermis followed by the basement membrane and the dermis
What are the key immunological components of SALT?
Langerhans cells, gamma/delta T cells, mast cells and macrophages
