Lecture 2.1: Lymphoma and Leukemia - Pediatrics

Question 1

What is the leading cause of death by disease past infancy among children in the United States?

Answer 1

Cancer

Question 2

What is the most common types of cancer diagnosed in chidlren ages 0-14 y/o in the US?

Answer 2

Leukemias

Question 3

What is the most common types of cancer diagnosed in adolescents 15-19 y/o; what is a common infectious agent implicated?

Answer 3

Lymphomas; EBV

Question 4

Which type of lymphoma is the most common malignancy in age group 15-19 y/o?

Answer 4

Hodgkin lymohoma

Question 5

What are B-symptoms?

Answer 5

• Unexplained fever 39°C
• Wt. loss >10% total BW over 6 months
• Drenching night sweats

Question 6

Any pt with persistent, unexplained LAD unassociated with an obvious underlying inflammatory or infectious process should get what?

Answer 6

A CXR to rule of mediastinal mass before undergoing LN biopsy

Question 7

What are the clinical manifestations of Wiscott-Aldrich Syndrome; how is it inherited; what is it a risk factor for?

Answer 7

• X-linked recessive
• Recurrent sino-pulmonary and ear infections
• Severe atopic dermatitis
• Bleeding –> 2’ to significant thrombocytopenia
• Risk factor for NHL***

Question 8

Burkitt lymphoma commonly manifests in pediatric populations how?

Answer 8

• Abdominal (sporadic type)

or

• Head and neck dz (endemic type) w/ involvement of BM or CNS

Question 9

Which genetic trisomy associated with both ALL and AML?

Answer 9

Trisomy 21

Question 10

Which type of leukemia constitutes 97% of all childhood leukemias?

Answer 10

Acute leukemia