Lecture 20 Flashcards
1
Q
What is an immune synapse?
A
any stable, flattened interface between a lymphocyte and any cell that it is recognizing
2
Q
What is a SMAC?
A
supra-molecular activation complex– the area of interface in an immune synapse
3
Q
/what does a cSMAC consist of?
A
TCR, CD3 signalling proteins, CD4/CD8 coreceptor, CD28 or ICOS
4
Q
What is a p-SMAC?
A
peripheral region enriched with adhesion proteins such as integrins that stablize the interaction of T cell and APC
5
Q
Which cell is the most potent activator of naive alpha beta T cells?
A
Dendritic cell
6
Q
Is activation of CD4 T cells essential in the development of adaptive immune responses?
A
Yes in CTL, T dependent B cell response, MP superactivation
No in T independent B cell response
7
Q
What are the five types of CD4 T cells?
A
th1:
