Lecture 2 - More skin ish Flashcards
Pemphigus vulgaris causes _____-_____ pattern on immunofluoresccence.
Basket-weaving pattern
Bullous Pemphigoid arises from linear deposition of Ig___ Abs (observeable on immunofluorescence) and complement in the stratum basale of the epidermis as the Abs react with hemidesmosomes. Keep in mind oral lesions tend to occur _____ (before or after?) skin lesions in Bullous Pemphigoid, while they oral lesions occur ______ (before or after?) skin lesions in Pemphigoid Vulgaris.
IgG
After
Before
Dermatitis Herpetiformis is a rare chronic papulovesicular eruption associated with ____-sensitive enteropathy and Ig____ deposits in the upper dermis. These Abs cross-react with _____, a protein involved in anchoring the stratum baslae of the epidermis to the dermis. Immunofluorescence shows speckled deposits of Ig___.
Relatives of patients with Dermatitis Herpetiformis should be tested for _____ disease (the one for gluten allergy.) Keep in mind Dermatitis Herpetiformis tends not to present with _____ lesions, unlike Pemphigoid Vulgaris and Bullous Pemphigoid.
Gluten-sensitive enteropathy
IgA depositions
Reticulin
IgA
Celiac disease
Oral lesions
Rosacea is a disorder characterized by persistent flushing, and _______ may result (permanent thickening of the nasal skin).
Rhinophyma
Erythema Nodosum is a septal _________ (inflammation of the hyodermal layer –> subQ fat layer) that is far more common in ______ (men or women?) and often appears on the anterior lower ____ (looks like bruising).
Panniculitis
Women
Leg
Nodular vasculitis (erythema Induratum) may scar, unlike Erythema Nodosum, and it is typically localized to the posterior lower _____. It is often associated with ____. Keep in mind this is a ______ panniculitis, while Erythema Nodosum is a septal panniculitis.
Leg
TB
Lobular panniculitis
______ ______ is characterized by a Herald Patch at onset, which is a single 2-4cm oval plaque, followed by the appearance of smaller lesions several days to weeks later. It’s commonly seen in teenagers after respiratory infections.
Pityriasis Rosea
Verruca Vulgaris is the common wart forming skin disease caused by _____. Microscopic findings show acanthosis and hyperkeratosis of the stratum ______. Be on the lookout for _____ (cells that show clearings/larger nuclei associated with HPV).
HPV
Corneum
Koilocytes
Molluscum Contagiosum is characterized by clusters of 1-6mm white papules with a central ____. It is caused by the Molluscum Contagiosum virus, which is a DNA poxvirus. It can be spread by direct contact or even fomites. Classic histological findings will show Molluscum bodies in which ______ becomes marginalized in the nucleus of these cells.
Central Pit
Chromatin
What are the three M’s of Herpes microscopic findings?
Multinucleation
Molding (nuclei mold together)
Marginalization (chromatin moves to margins of nucleus)
When varicella zoster reactivates as shingles, it affects a single _______ (zone of skin.)
Dermatome
What is the cause for Hand, fFoot, and Mouth disease?
Cocksakie virus (typically A)
______ is a superficial Staph Aureus infection (also strep pyogenes). There are two clinical presentations. 1. _____, which is caused by epidermolytic toxin. 2. Non-____, which is characterized by honey crusts around the lesions.
Impetigo
Bullous
Non-bullous
_______ is an infection with characteristic streaking up the skin as it travels up the lymphatics. It is most often caused by Strep pyogenes (sometimes by staph aureus).
Cellulitis
Sandpaper rash and strawberry tongue are characteristic of ______ fever caused by Strep pyogenes.
Scarlet fever
