Lecture 2 - Macromolecules and their structures

Question 1

Primary protein structure

Answer 1

sequence of amino acids

Question 2

Secondary protein structure

Answer 2

Hydrogen bonding of peptide backbone

Question 3

Tertiary protein structure

Answer 3

3-d folding pattern

Question 4

Quaternary protein structure

Answer 4

protein consisting of more than one amino acid chain

Question 5

Amino acids naturally occurs as which enantiomer

Answer 5

L-form

Question 6

Hydrophobic amino acids

Answer 6

Ala, Val, Pro, Leu, Ile, Phe

Question 7

Negative amino acids

Answer 7

Asp, Glu

Question 8

Positive amino acids

Answer 8

Lys, Arg, His

Question 9

Hydroxyl amino acids

Answer 9

Ser, Thr, Tyr

Question 10

Amide amino acids

Answer 10

Asn, Gln, Trp

Question 11

Non-standard amino acids

Answer 11

Gly, Met, Se-Met

Question 12

Arginine and aromatic residues can participate in

Answer 12

polar pi stacking

Question 13

Surfaces formed by polar amino acids are solvated with water molecules, usually only observed with resolution better than

Answer 13

2.8 angstroms

Question 14

In which beta sheet are hydrogen bonds at a 180 degree angle?

Answer 14

anti-parallel

Question 15

Protein loops can often be highly dynamic, and therefore

Answer 15

unresolved in protein structures

Question 16

Membrane proteins are approximately what percentage of the human proteome?

Answer 16

33%

Question 17

Membrane proteins represent about what percentage of all protein structures in the PDB?

Answer 17

1%

Question 18

Proteins can either form a single domain or many depending on

Answer 18

function

Question 19

Many proteins are not stable or active as

Answer 19

monomers

Question 20

Pyrimidine bases

Answer 20

Cytosine, uracil, thymine

Question 21

Purine bases

Answer 21

Adenine, guanine

Question 22

DNA contains a ______ which often serves as the site for protein interactions

Answer 22

major groove

Question 23

The Zn-finger motif interacts with DNA by binding with the

Answer 23

major groove

Question 24

Leucine zipper binds the

Answer 24

major groove