Lecture 2: Development of immune system and nature of immune responose Flashcards
How can cells of the immune system be identified?
The ‘CD’ markers they express on their surface. (cluster of differentiation).
What CD markers do T-cells have?
T cells will have CD3+, and can also have CD4+ or CD8+
What CD marker do B-cells have?
B-cells will have mlg+, or membrane immunoglobulin. Gained when some antibodies the B-cells produce get embedded in the lipid bilayer.
What part of the immune system do B-cells and T-cells have a role in?
The adaptive immune system.
How do B-cells function in the adaptive immune system?
Each B-cell will use genetic recombination to produce unique antibody isotypes. These antibodies are unique to the a specific antigen, and will function on the surface of the B-cell. When B-cell surface receptors bind to an antigen, more immunoglobulins are produced and released to mark invaders for immune response.
T-cells have what role in the adaptive immune system?
Alpha and beta T-cells will generate unique T-cell receptor genes, via genetic recombination. Once an antigen binds to these receptors
What is the 12/23 rule?
Combinatorial diversity is?
What are epitopes?
Where do lymphocytes mature?
T-cells mature in the thymus and B cells mature in the bone marrow.
How are T-cells identified and classified?
T-cell
Why do T-cells not recognise intact antigens?
What cells can express HLA-II?
What is the difference between HLA-I and HLA-II?
