Lecture 2: Clinical Notes Flashcards
What are the two mechanisms through which cell death in the cochlear occurs?
1) necrosis
2) apoptosis
Status of a cell is determined by health of the ___________ and the availability of _____
Mitochondria
ATP
Which type of cell death is passive and which is active?
Passive = necrosis Active = apoptosis
Which type of cell death occurs through swelling of the cell body, losing of a plasma membrane, spillage of cell contents, and an inflammatory response?
Necrosis
Which type of cell death occurs through condensation of chromatin, shrinkage of cytoplasm, blebbing of plasma, and has no spillage and no inflammation
Apoptosis
During apoptosis how does the cell die?
It breaks apart into lots of small pieces
During neurosis how does the cell die?
Spills and enflames
Why does apoptosis happen?
Unnecessary cells kill themselves to stop wasting energy
Apoptosis is an _____________ reaction that the cell does __ ______
Enzymatory
To itself
What was the previous assumption about apoptosis?
That it stops after development/neural pruning
Apoptosis has a ____ energy requirement
High
Necrosis can cause a _____-_______ of ____________ responses
Chain-reaction
Inflammatory
What does cochlear apoptosis look like on imaging?
Shrunken/condensed nucleas
what does cochlear neurosis look like on imaging?
Increased cell size and diffused staining
Now, what is the accepted predominant form of acquired hair cell death in the cochlea?
Apoptosis
