Lecture 2: Amino acids in protiens

Question 1

hemoglobin mutation where there is a neutral amino acid in glu6

Answer 1

Sickle cell disease

Question 2

hemoglobin mutation where there is a positive amino acid in glu6

Answer 2

Hemoglobin C disease

Question 3

Glycosylation vs Glycation

Answer 3

Glycosylation - normal, enzyme mediated that increases solubility of protein. Can be O linked (Negative AAs) or N linked (Positive AAs -arginine). These are used on red blood cell surface to determine ABO blood type.

Glycation - not normal, hemoglobin glycated by blood glucose from too high of blood sugar, determind by Hb A1C level.

Question 4

Binding lipids to proteins

Answer 4

Allows proteins to be inserted in plasma membrane without having a transmembrane region.