Lecture 2 Flashcards
What percentage of the intracranial vault does each component make? Brain, Blood and CSF
Brain: 80 - 85%
Blood: 5 - 10%
CSF: 10 - 15%
What are the 2 main blood supplies to the brain?
Bilateral Carotid arteries
Bilateral Vertebral arteries
Where does the left carotid artery arise from?
The aortic arch
Where does the right carotid after arise from?
The Innominate Artery
What do the carotid arteries bifurcate into?(2)
- External carotid artery
2. Internal carotid artery
Where does the internal carotid artery enter the skull?
At the base of the skull
Where does the External carotid artery enter the skull?
It does NOT enter the skull, it remains superficial to the skull
What 3 main areas do the internal carotid arteries supply?
- Circle of Willis
- Ophthalmic artery (supplies the eye)
- Bifurcates into the anterior & middle cerebral arteries
What arteries arise from the subclavian arteries and supply the Circle of Willis?
The vertebral arteries
Where do the vertebral arteries arise from?
Subclavian arteries
What part of the brain do the vertebral arteries supply?
Circle of Willis
Describe how the venous blood of the brain drains?
Drains into the VENOUS SINUSES which lie between the layers of the DURA MATER & drain into the INTERNAL JUGULAR VEIN
Describe 4 important aspects of venous sinuses of the brain:
- Valveless
- Blood can flow back & forth
- Negative pressure (air embolism)
- Little influence by autonomic system
Describe why there brain is subject to air embolisms?
Venous sinuses have negative pressure, which can lead to air embolism
What do the meninges cover (2) and what do the consist of (3)?
- Covers BRAIN & SPINAL CORD
- Consists of DURA MATER, ARACHNOID MEMBRANE, PIA MATER
The ____A_____ is anchored to the brain by ____B_____, which forms the _____C_____.
A. Pia mater
B. Astrocytes
C. Blood-brain barrier
The Blood-brain barrier allows passage/transport of: (4 - with examples)
- Small molecules (H2O, O2, CO2)
- Lipophilic molecules (EtOH, heroin)
- Passive transport of glucose
- Active transport of amino acids/NT precursors
The blood-brain barrier PREVENTS the passage of: (2)
- Large molecules (dopamine)
2. Charge (ionized) molecules
What does the dura mater consist of? What is between these layers?
What is the function of the dura mater?
- Consists of outer & inner layer
- Dural Sinus between the layers
- Drains the CSF
List the layers from the brain to the skull:
- Brain
- Pia mater
- Subarachnoid space
- Arachnoid membrane
- Dura mater
- Skull
Where is an epidural hematoma located? What is usually the artery of origin?
- Bleeding between the skull & dura mater
- Usually originating in meningeal arteries
Where is a subdural hematoma located? What is usually the artery of origin?
- Bleeding between the dura & arachnoid mater
- Usually originating from tears in BRIDGING VEINS
Where is a subarachnoid hematoma located? What is usually the cause?
- Bleeding between the arachnoid membrane & Pia mater
- Usually from a ruptured cerebral aneurysm