Lecture 2 Flashcards
1
Q
What is CDC28 required for?
A
passing start and G2/M
2
Q
What is CDC2 required for?
A
G2/M
3
Q
What is the role of CDC25?
A
Removes inhibitory phosphate from cdk1
4
Q
What is the role of wee1?
A
phosphorylates cdk1 inhibitory
5
Q
What is the role of CAK?
A
Provides the activational phosphorylation to the T-loop of the Cdk1.
6
Q
Three mechanisms of CDK regulation:
A
1) need to bind cyclin
2) need activating phosphorylation
3) Inhibited by inhibitory phosphorylation
(4) Inhibited by proteins that bind the cyclin-CDK complex)
