Lecture 2-3: Cells of the Immune System

Question 1

In the lymph node, B cells are located in the

Answer 1

follicles

Question 2

In the lymph node, T cells are located in the

Answer 2

paracortex

Question 3

The outer cortex consists mainly of the

Answer 3

B cells, arranged as follicles

Question 4

True or false:

The spleen receives circulating lymph and produces ECF has lymphatic drainage

Answer 4

False.

Question 5

Three types of granulocytes

Answer 5

Neutrophils
Basophils
Eosinophils

Question 6

Basophil function

Answer 6

Promotion of allergic responses and anti-parasitic immunity
Recruitment to site of IgE-mediated allergic reactions
Release of histamine and cytokines (IL-4, IL-13)
Involved in helper T cell differentiation

Question 7

Function of eosinophils

Answer 7

Killing of antibody-coated parasites

Question 8

Neutrophils

Answer 8

Phagocytosis and activation of bactericidal mechanisms

Possess ability to effectively enter inflamed tissue

Question 9

A circulating monocyte that leaves the blood and enters a tissue is by definition called a

Answer 9

macrophage

Question 10

Function of MAST cells

Answer 10

Found in connective tissues
Critical role in leukocyte recruitment (increases vascular permeability)
Release of histamine and cytokines (IL-4, IL-13)
Fc receptor cross-linking

Question 11

Tfh transcription factor

Answer 11

Bcl-6

Question 12

Th2 transcription factor

Answer 12

Gata3

Question 13

Th1 transcription factor

Answer 13

T-bet

Question 14

Th17 transcription factor

Answer 14

RorγT

Question 15

Treg/iTreg transcription factor

Answer 15

FOXP3

Question 16

B cells mature in the

Answer 16

bone marrow

Question 17

T cells mature in the

Answer 17

thymus

Question 18

Inhibitory cytokines

Answer 18

TGF-β, IL-10